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Page 6 of 13                                                                                     Zahrai et al. Vessel Plus 2023;7:32  https://dx.doi.org/10.20517/2574-1209.2023.100



                                          cohort                                                                                                               complications; in-  Patients who underwent CABG within
                                                                                                                                 2-3                           hospital mortality  24 h were more likely to develop any
                                                                                                                                                                                 complications compared to those in 2-
                                                                                                                                 4-7                                             3 and 4-7 days groups, respectively
                                                                                                                                                                                 (OR = 1.22, 95% CI 1.05-1.41, and OR
                                                                                                                                                                                 = 1.18, 95% CI 1.01-1.36, respectively).
                                                                                                                                                                                 Differences in complications between
                                                                                                                                                                                 2-3 and 4-7 days groups were not
                                                                                                                                                                                 statistically significant (OR  =  0.97,
                                                                                                                                                                                 95% CI 0.85-1.11)

                                                                                                                                                                                 Odds of in-hospital mortality was
                                                                                                                                                                                 higher in the < 1 day, compared to 2-3
                                                                                                                                                                                 days group (OR  =  1.85, 95% CI 1.52-
                                                                                                                                                                                 2.25) and 4-7 days group (OR  =  2.21,
                                                                                                                                                                                 95% CI 1.82-2.68). The latter two
                                                                                                                                                                                 groups did not differ in terms of in-
                                                                                                                                                                                 hospital mortality
                              Liakopoulos  Prospective   STEMI,        618 STEMI              CABG of any type   STEMI: 68.3 ±   < 1                           In-hospital all-
                              et al.      registry cohort NSTEMI                                                 10.3                                          cause mortality   In-hospital mortality occurred two-
                                    [38]
                              (2020)                                   1,218 NSTEMI                                              1-3                                             fold higher in STEMI patients who had
                                                                                                                 NSTEMI: 66.6 ±                                                  CABG < 24 h compared both to those
                                                                                                                 11.3            > 3                                             who had CABG > 72 h and to those
                                                                                                                                                                                 between 24-72 h

                                                                                                                                                                                 CABG timing did not affect the in-
                                                                                                                                                                                 hospital mortality of patients with
                                                                                                                                                                                 unstable angina or those with NSTEMI

                              Bianco et al.  Retrospective  STEMI      368 STEMI              Isolated CABG      66.0 (Range     < 1                           All-cause
                                    [40]
                              (2021)      cohort                                                                 58.0-74.0)                                    mortality         All-cause mortality postop was
                                                        NSTEMI         1,690 NSTEMI                                              > 1                                             significantly higher < 1 day, compared
                                                                                                                                                                                 to the > 1 day group[Hazard ratio (HR)
                                                                                                                                                                                 (95% CI) = 0.63 (0.42-0.97)]. After
                                                                                                                                                                                 risk factor adjustments, there was no
                                                                                                                                                                                 difference in terms of mortality
                                                                                                                                                                                 (4.15% vs. 4.58%, P = 0 .62). Timing
                                                                                                                                                                                 of CABG did not impact mortality in
                                                                                                                                                                                 either STEMI (HR = 0.57 (0.25-1.29)
                                                                                                                                                                                 or NSTEMI (HR = 0.99 (0.56-1.76))
                                                                                                                                                                                 groups

                              Lang et al.   Systematic   STEMI         38,469 STEMI           CABG of any type   STEMI: 63.7                                   In-hospital       OR between < 24 h CABG and > 24 h
                                    [34]
                              (2022)      review and                                                                             Many subdivisions ranging from   mortality      CABG groups was 2.65 (95% CI:
                                          meta-analysis  NSTEMI        3,405 NSTEMI                              NSTEMI: 67.2    < 0.25 to 15-30 (STEMI)                         1.96-3.58). This was 3.88 (2.69-5.60)
                                                                                                                                 < 1 to 3-21 (NSTEMI)                            for undefined STEMI/NSTEMI, 2.62
                                                        Undefined      72,675 Undefined                          Undefined       < 2 to > 42 (Undefined                          (1.58-4.35) for STEMI, and 1.24 (0.83-
                                                        STEMI/NSTEMI STEMI/NSTEMI                                STEMI/NSTEMI:  STEMI/NSTEMI)                                    1.85) for NSTEMI groups
                                                                                                                 65.9
                                                                                                                                                                                 OR between < 48 h CABG and > 48 h
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