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Sun et al. Soft Sci. 2025, 5, 18  https://dx.doi.org/10.20517/ss.2024.77        Page 13 of 26

               Memristors enable high-density and parallel integration through crossbar array architectures for efficient
               and scalable neural network implementations. Their nonvolatile nature ensures data persistence without
               continuous power, reducing overall energy consumption and enhancing system reliability. They also
               support CIM operations, effectively mitigating the von Neumann bottleneck by performing calculations
               directly within the memory matrix, which accelerates processing speeds and lowers energy costs.
               Additionally, memristors exhibit low power consumption and minimal heat generation, making them an
               ideal option for large-scale, energy-efficient neuromorphic systems. They provide flexible synaptic behavior
               through tunable resistance states that can closely mimic the dynamic synaptic connections of biological
               brains, which enhances learning and memory capabilities. The simplified device structure of memristors
               facilitates easier manufacturing and cost-effective production, while their high scalability and integration
               compatibility with existing semiconductor technologies enable seamless incorporation into advanced
               neuromorphic architectures as well. For example, the coexistence of negative differential resistance (NDR)
               and resistance switching (RS) behaviors in a memristive device with Ag/ZnOx/TiOy/indium tin oxide
               (ITO) structure was fabricated to sense temperature and information storage . This multifunctional device
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               leveraged the dual properties of NDR and RS to enhance both sensing accuracy and data retention
               capabilities. Besides inorganic oxides, polymer-based biomaterials were also used as active layers in the
               production of memristors. A polyurethane sponge sensor pressure sensor and chitosan-based memristor
               were combined to realize the perception of external signals and the functions of perception, memory, and
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               data processing by adjusting the synaptic weight  [Figure 5A]. The circuit connection diagram of single
               pressure and a memristor is shown in Figure 5B, and the I-V curves, current on/off ratio, and repeated test
               performance of chitosan-based memristor are shown in Figure 5C. A pressure sensory array and memristive
               spiking neuron array were integrated to acquire stimulation, process and recognize the pressure signals. The
               instantaneous spike frequency maps obtained by the memristive spiking neural array were used to train the
               SNN, and the neural network successfully extracted and learned the spatial features of spike frequency maps
               for different letters, achieving a classification accuracy of approximately 98%  [Figure 5D-F]. The
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               integration of a pressure sensor and NbOx-based memristor is illustrated in Figure 5G, using the circuit
               diagram of spiking nociceptor by switching high resistance state (Roff) and low resistance state (Ron) to
               generate spiking signals [Figure 5H], an intelligent sensor is able to detect harmful stimuli  [Figure 5I].
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               Besides this, the memristor with a Ti/Pt/NbOx/Ti/Pt structure integrated the pressure sensors to act as
               multisensory perception. A 3 × 3 array of multimode-fused spiking neuron was fabricated [Figure 5J], and
               the circuit diagram of spiking neuron was used to generate the spiking signals [Figure 5K]. Through this
               method, temperature and pressure analog information were fused into one spike train; a SNN algorithm
               was simulated to recognize objects  [Figure 5L].
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               NEURAL NETWORK ALGORITHMS
               AI learning techniques have been integrated into sensory systems to enhance their ability to adapt, learn,
               and make accurate predictions based on the input data. AI learning can be broadly categorized into two
               main approaches: global error-driven and local neuroscience-inspired learning. The global error-driven
               learning approach focuses on minimizing a global error metric across the entire model. Techniques such as
               gradient descent are commonly used, where the system calculates the difference between predicted and
               actual outputs and adjusts weights across the entire network to reduce error. Deep learning models, such as
               neural networks trained with backpropagation, are prime examples of global learning. Although these
               models often require extensive datasets and substantial computational resources, they can achieve high
               accuracy in complex tasks.

               Inspired by the human brain, local learning focuses on updating the model through mechanisms that utilize
               information available at individual neurons or specific layers. Local learning rules, such as Hebbian learning
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