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Page 2 of 11                             Kim et al. Soft Sci 2024;4:12  https://dx.doi.org/10.20517/ss.2023.50

               INTRODUCTION
               Advanced materials and associated mechanics have opened pathways for transforming conventional, rigid,
                                                                          [1]
               planar integrated circuits into stretchable, flexible, soft electronics . Theoretical studies, supported by
               mechanical modeling, such as finite element analysis (FEA), have revealed key features and characteristics
               of these unusual material structures, including the optimization of three-dimensional (3D) buckled
                        [2]
               electronics . The unique properties of these materials, which allow for conformal contact with the body,
               have led to numerous pioneering works on new classes of soft devices in biomedical applications known as
               bioelectronics. Skin-interfaced electronics, a specific class of soft electronics, have established the
               foundations for continuous clinical-grade monitoring and are well investigated and summarized in terms of
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               materials selection, design, fabrication, and system integration . Nevertheless, the interaction between
               biosystems and soft electronics often results in non-trivial coupled mechanics, which requires further effort
               to characterize the biomechanics, bioelectronics, and their interactions.

               This article underscores the latest advances in computer vision techniques and their impact on advancing
               soft-electronic systems, intending to refine the next generation of skin-interfaced electronics through a
               thorough characterization of associated biomechanics and, conversely, how these biomechanics influence
               electronic design. The process is iterative, encompassing the development of soft electronics, the
               identification of coupled mechanics, and their quantification using computer vision methods, as depicted in
               Figure 1. We delineate (i) pioneering computer vision techniques employed in skin-interfaced electronics;
               (ii) the interaction of mechanics in mechano-acoustic (MA) sensors; and (iii) the interconnected mechanics
               in haptic systems. Final remarks outline expected advancements in computer vision techniques and their
               projected applications across diverse areas within the soft electronics field.

               COMPUTER VISION IN SOFT ELECTRONICS
               Computer vision methods, also referred to as optical measurement systems, are employed across various
               research areas within continuum mechanics, including studies on fluid flows , solid deformations , and
                                                                                                    [7]
                                                                                  [6]
                              [8]
               wave phenomena . These approaches provide non-contact, non-intrusive measurements with high spatial
               and temporal resolutions. Recently, they have been instrumental in offering robust mechanical insights for
               soft electronic devices, particularly in biomedical and biomechanical applications, revealing essential
               coupled mechanics between biological systems and soft electronic devices. The most representative
               computer vision techniques applied in soft electronics are summarized in Table 1. When employing one or
               a combination of these techniques, several factors must be considered, namely, applications, key outputs,
               the need for fiducial points, the suitable frame of reference, dimensionality, processing time, and resolution.

               Particle image velocimetry (PIV) is an advanced optical measurement technique that allows for the detailed
               analysis of the flow velocity field by tracking the collective motion of tracer particles within a fluid . The
                                                                                                    [9]
               method operates by observing these particles from an Eulerian reference frame. Essential to the PIV setup is
               introducing seeding particles into the flow, chosen for their ability to follow the fluid's motion with minimal
               impact - a property quantified by the Stokes number. A typical PIV system includes one or more high-
               resolution cameras synchronized with a laser illumination source. This synchronization is critical for
               capturing the scattered light from particles at precise intervals, particularly in a dual-pulse arrangement
               where two images are taken in rapid succession. These images are then dissected into smaller interrogation
               regions. Within each subregion, the displacement of particle groups is determined by employing spatial
               cross-correlation, providing a vector map of flow velocity and patterns essential for the resolution of
               complex turbulent flows. The technique is particularly useful for correlating cardiac or respiratory flows to
                     [10]
               sensors .
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