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Page 8 of 9                                                 Alimi et al. Plast Aesthet Res 2020;7:5  I  http://dx.doi.org/10.20517/2347-9264.2019.39

               Table 7. Review of outcomes by mesh plane location with the use of biologic mesh [15]
                Biologic mesh    Onlay   Inlay  Sublay (Retromuscular)  Sublay (Intraperitoneal/Preperitoneal)  P value
                Infection        21.3%   23.3%       18.1%                    19.2%                0.814
                Seroma/Hematoma  32.3%   10.8%       11.2%                    8.0%                 < 0.001
                Mesh removal     0.0%    0.0%        1.6%                     0.5%                 0.359
                Recurrence       28.6%   29.1%       11.6%                    11.2%                0.016
                Overall complication  57.3%  54.2%   40.9%                    40.9%                0.197


               CONCLUSION
               Half a million patients undergo ventral hernia repair annually in the United States as a result of incisional
               hernias, failed repairs, de novo abdominal wall defects, and abdominal catastrophes. Although the standard
               approach of hernia repair has been well studied, the ideal anatomic location of mesh placement is still
               highly debated. Sosin et al.’s  systematic review of mesh placement found that anatomic location can
                                        [15]
               change outcomes in hernia recurrence. Analysis of 51 articles showed that, of the four mesh techniques,
               namely onlay, interposition, sublay-retromuscular, and sublay-preperitoneal/sublay-peritoneal, the sublay-
               retromuscular approach is associated with the lowest recurrence rate, whereas the interposition technique
               is associated with the highest recurrence rate. There was no statistical difference in other complication
               rates among the four groups, which included postoperative infection, hematoma/seroma formation,
               mesh explantation, and mortality. Overwhelmingly, the inlay placement of mesh is the least favored and
               should be avoided if possible. In the minimally invasive approach, both robotically and laparoscopically,
               the sublay-preperitoneal/sublay-intraperitoneal repair has proven very useful with similar perioperative
               complications and recurrence rates. In regards to mesh selection, in accordance with the recommendations
               of the VHWG, we recommend that all ventral hernias be reinforced with mesh regardless of whether the
                                                [22]
               midline fascia can be reapproximated . While strong recommendations for the use of synthetic versus
               biologic mesh are unclear in patients with VHWG Grades 2 and 3, biologic mesh’s benefit is clear in grossly
               contaminated wounds and synthetic mesh is recommended in VHWG Grade 1 patients.

               DECLARATIONS
               Authors’ contributions
               Conceived the concept of the review and are the primary authors of the manuscript: Alimi Y, Bhanot P
               Performed significant writing and review of the final manuscript: Merle C
               Provided feedback, essential data gathering and review of the manuscript: Sosin M
               Provided principal figures in the article: Mahan M
               All authors read and approved the final manuscript.


               Availability of data and materials
               Not applicable.

               Financial support and sponsorship
               None.

               Conflicts of interest
               All authors declared no conflicts of interest. Dr. Parag Bhanot is a consultant to Allergan.

               Ethical approval and consent to participate
               Not applicable.

               Consent for publication
               Not applicable.
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