Page 469 - Read Online

Citterio et al. Plast Aesthet Res 2020;7:41 I http://dx.doi.org/10.20517/2347-9264.2020.29 Page 13 of 20

Sites treated with PDL grafts in PDL grafts Both groups showed a significant without statistically significant cells sheets were reported The test protocol resulted in a of CAL gains, PPD reductions were reported PD reduction, CAL gain and bone reported
Results demonstrated significant improvement in vertical and horizontal defect fill, PD, and CAL at 3 and 6 months compared to pre-surgical values. The difference determined for the PD values of both groups at a statistically significant degree in favor of grafted sites was maintained at all observation periods. No foreign body reaction was observed increase in the alveolar bone height, differences between groups. Regarding the clinical p

Outcome variables Clinical: PI, GI, PD, GR, Radiographic: linear and volumetric evaluation Volumetric defect fill by impression of the defects Histologic analysis by gingival biopsy from one patient Radiographic (main outcome): Increase in alveolar bone height (rx bone fill) Clinical: CAL, PPD, REC Safety assessment: blood and urine examination Clinical: PI, BPI, CAL, PPD, relative gingival marginal level Radiographic: linea

Follow-up 6 months, with CAL a surgical re- entry 12 months 6 months 12 months CAL

Treatment groups Test: coronally positioned flap with autogenous PDL grafts that were obtained from third molars Control: coronally positioned flap alone Test: GTR and PDLSC sheets in combination with demineralized bovine bone matrix Control: GTR and demineralized bovine bone matrix without stem cells Test: ODF applying allogeneic UC- MSCs on a β-TCP scaffold in combination rh- PDGF-BB Control: OFD Test: m

Number of patients 10 patients 20 10test/10 control 30 patients 41 defects: 20 test/21 control 14 patients 24 defects: 12 test/ 12 control 29 patients 29 defects: 15 test/14 control
Table 3. Summary of RCT on periodontal regeneration with mesenchymal stem cells

Defect type Class II mandibular defects: furcation defects Intrabony defects Intrabony defects Intrabony defects

Stem cells handling Direct application of PDL tissue collected from an extracted molar, into the defect Collection from an extracted molar, isolation, culture, characterization and engineering into cells sheets in laboratory Collection from the hospital in a sterile tube Followed by isolation and culture on β-TCP scaffold Mechanical dissociation of the dental pulp of an extracted tooth by the use of a biological

Cell type PDLSC PDLSC UC-MSC DPSC

Study design RCT with a split mouth design single- center RCT Parallel designed RCT double- blind, prospective RCT

Akbay et al. [112] Chen et al. [120] Dhote et al. [123] Ferrarotti et al. [122] Parallel,

Author 2005 2016 2015 2018