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BMSC group showed reported -Immunohistochemical: GFP, showed newly formed of bone All the groups with PRP showed regeneration of bone and cementum. BMSC showed the best regeneration. and control group Genetic expression of ASCs and DPSCs are bone Bone, cementum and ligament resulted regenerated in both PDLSC regeneration
Results neocementum along the denuded dentin with bone e ligament formation. No root resorption or ankylosis Defects treated with MSC cementum, PL and alveolar potential for periodontal Test group showed higher percentage of cementum and PL regeneration. Bone formation was equal in test similar. Transplanted ASCs regenerate PL, and alveolar allogenic and autogenous Both cell types improved PL and bone tissue had been generated

-Histological: HES, Azan staining -Histomorphometric -Histological: HES Proliferating Cell Nuclear Antigen (PCNA) -Histological: HES -Histomorphometric -Histological: HES -Histomorphometric -anatomical -histological -immunohistochemical -Clinical: CAL, PD, GR, blood and biochemical tests -Histological: HES -Histomorphometric -Radiological: CT -Clinical: CAL, PD, GR -Histological: HES -Radiological: CT -Clinica
Analysis -Histological: HES, toluidine -Radiological: CT, micro-CT -Biochemical: compressive

Study period 1 month 1 month 2 months 2 months 15 weeks 3 months 3 months 6, 12 months -SEM

Table 2. Summary of available evidence for periodontal regeneration with mesenchymal stem cells in animal studies
Treatment group (a) BMSC + AC (b) AC (a) BMSC + AC (b) no treatment (a) BMSC+PRP (b) autogenous cortical bone + PRP (c) PRP (d) autogenous cortical bone (e) no treatment (a) BMSC + Demineralized bovine bone matrix (b) Demineralized bovine bone matrix (a) collagen + rBMP2 (b) collagen (a) PDLSC autologous + HA- β-TCP (b) PDLSC allogenic + HA-β- (c) PDLC autologous and allogenic + HA-β-TCP (d) HA + β-TCP (e) empty defect (a)

Defect type Class III furcation defects 4 mm deep Class III furcation defects 4 mm deep 6 (a, b, c, d, Class II furcation defects 5 mm × 2 mm Intrabony defects 4 mm × 4 mm Extraction sockets defects 3 mm × 7 mm × 5 mm TCP Intrabony defects 5 mm × 7 mm × 7 mm Root-shaped implant socket 4.1 mm × 10 mm

Defects per group Unclear 6 e) 9 (a, b) 14 (a,b) 6 (a, b, c, d, Intrabony e) 6 (a, b, c) 9 (b)

Animal model DOG Beagle female 12-20 months old DOG Beagle female 12-20 months old DOG Mongrel male 14-22 kg New Zealand withe RABBIT 2-12 months old MINIATURE PIG female Wuzhishan, male Guizhou 6-8 months old MINIATURE PIG female 9-12 months old MINIATURE PIG 46 (a) 18 months old

Biomaterial AC AC PRP autologues Demineralized DOG Mongrel bovine bone matrix Collagen HA/β-TCP + gelatin membrane HA/β-TCP HA/TCP

Cell type BMSC BMSC BMSC BMSC rADSCs rDPSCs PDLSC PDLSC SHED PLSC DPSC

Kawaguchi et al. [72] Hasegawa et al. [53] 2006 Simsek et al. [70] 2012 Paknejad et al. [68] 2015 Hung et al. [85] 2011 Ding et al. [86] 2010 Fu et al. [87] 2014 Gao ZH et al. [91] 2016

Author 2004