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Ohashi. Plast Aesthet Res 2020;7:26 Plastic and
DOI: 10.20517/2347-9264.2020.15 Aesthetic Research

Original Article Open Access

Cryopreserved fat: our clinical experience and
applications

Masanori Ohashi

The Clinic Tokyo, Minato-ku, Tokyo 106-0031, Japan.
Correspondence to: Dr. Masanori Ohashi, The Clinic Tokyo, Nishiazabu 3-16-23 Minato-ku, Tokyo 106-0031, Japan.
E-mail: ohashi@theclinic.jp

How to cite this article: Ohashi M. Cryopreserved fat: our clinical experience and applications. Plast Aesthet Res 2020;7:26.
http://dx.doi.org/10.20517/2347-9264.2020.15

Received: 29 Jan 2020 First Decision: 25 Mar 2020 Revised: 27 Apr 2020 Accepted: 7 May 2020 Published: 23 May 2020

Science Editor: Jian-Xing Song Copy Editor: Jing-Wen Zhang Production Editor: Jing Yu

Abstract
Aim: Cryopreservation of fat is an effective method for repeat fat grafting, but there are few reports about
the clinical use of cryopreserved fat. The aim of this study was to determine the effectiveness and safety of
cryopreserved fat for clinical use.

Methods: Between Aug 2015 and Dec 2018, we investigated 590 patients who underwent fat harvesting at our
clinic. The harvested fat was cryopreserved at a temperature of -196 °C at a cell processing center and injections
were performed in our clinic.

Results: Of the 590 patients studied, 216 (312 cases) have undergone fat injections so far. Volume augmentations
using harvested fat, such as facial and breast augmentations, were performed on 180 patients. For 84 patients,
harvested fat was utilized only for revitalization/fertilization purposes, such as to improve skin condition.
There were no severe complications in any patients. However, volume maintenance was rarely observed. Skin
rejuvenation effects were comparable to that in cases using fresh fat.

Conclusion: The clinical use of cryopreserved fat is thought to be safe and effective.

Keywords: Cryopreserved fat, frozen fat, fat grafting, skin rejuvenation

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
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