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Page 8 of 10                                        Wiedner et al. Plast Aesthet Res 2020;7:10  I  http://dx.doi.org/10.20517/2347-9264.2019.51

























                             Figure 8. Lipedema Stage 3 patient before and after five sessions of liposuction in the lower legs

               complications as well as persistent postoperative edema due to damage to the lymphatic vessels. As a
               result, conventional dry liposuction under general anesthesia was therefore contraindicated in lipedema
                      [34]
               patients .
               Nowadays, the “wet”, “super-wet”, and “tumescent” techniques are used, which are less likely to damage
               the lymphatic system compared to the conventional “dry” technique. The use of microcannulas as well as
               new liposuction techniques such as power-assisted liposuction with vibrating cannulas or waterjet-assisted
               liposuction have been shown to further minimize tissue trauma and complication rates.


               When performing liposuction in lipedema patients, the crisscross technique, which is commonly used in
               aesthetic surgery, is contraindicated because of the higher risk of harming lymph vessels with consecutive
               development of lymphedema. Therefore, it is of great importance to take the lymph vessel anatomy into
               account and move the cannula parallel to the lymph vessels in order to save them. This is why more
               incisions are usually needed to remove the fat from the affected area.


               Since 2005, guidelines of the German Society of Phlebology recommend liposuction as an integrated
                             [35]
               part of therapy . Tumescent liposuction has been demonstrated to reduce disproportions and pain
                          [36]
               permanently , stop progression of the disease [35,36] , and improve quality of life [37-40] . In addition, surgical
               therapy may reduce the amount of necessary conservative therapy [38,40] . Weight management is an important
               requirement for maintaining the benefits of liposuction. There are reports that fat can re-accumulate in
               those who put on weight after liposuction.


               Most patients undergoing liposuction for lipedema require several treatments over several months.
               According to the guidelines, more than 4-6 liters of fat per session should not be removed because the risk
               of cardiopulmonary complications increases with increasing blood and fluid loss. Electrolyte imbalances
               are particularly dangerous. Usually, a minimal interval of at least three months between the sessions is
               recommended. Figure 8 shows a 36-year-old patient after five sessions of liposuction.


               In conclusion, Lipedema is a frequently unrecognized and misdiagnosed disorder. Clinicians should be
               aware of clinical signs and clearly distinguish the condition from other entities. Accurate diagnosis and
               treatment are essential because they determine the patient’s prognosis. A targeted therapy for lipedema is
               not known because the exact etiology of the disorder is not clarified yet. Decongestive physical therapy
               is the basic conservative treatment, which is usually necessary lifelong. However, liposuction has led
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