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García Botero et al. Plast Aesthet Res 2018;5:15 Plastic and
DOI: 10.20517/2347-9264.2018.09 Aesthetic Research

Systematic Review Open Access

A systematic literature review of the management of
chronic venous ulcers with autologous fibrin matrix

with or without growth factors

Alejandra García Botero , Jorge Ernesto Cantini Ardila , Luis David Devoz Borja , Viviana Gómez-Ortega 2
1
1
1
1 Plastic and Reconstructive Surgery Department, Hospital de San José, Fundación Universitaria de Ciencias de la Salud, Bogotá
110111, Colombia.
2 Plastic and Reconstructive Surgery Department, Fundación Santa Fé de Bogotá, Bogotá 110111, Colombia.
Correspondence to: Dr. Alejandra García Botero, Servicio Cirugía Plástica Estética y Reconstructiva - Pabellón Arcadio Forero,
Carrera 19 No. 8 - 32, Bogotá 110111, Colombia. E-mail: alebotero@hotmail.com
How to cite this article: García Botero A, Cantini Ardila JE, Devoz Borja LD, Gómez-Ortega V. A systematic literature review
of the management of chronic venous ulcers with autologous fibrin matrix with or without growth factors. Plast Aesthet Res
2018;5:15. http://dx.doi.org/10.20517/2347-9264.2018.09

Received: 24 Feb 2018 First Decision: 21 Mar 2018 Revised: 3 Apr 2018 Accepted: 4 Apr 2018 Published: 23 Apr 2018

Science Editor: Raúl González-García Copy Editor: Guang-Zhe Zhu Production Editor: Cai-Hong Wang

Abstract
Aim: To evaluate available evidence for the effective management of venous leg ulcers with fibrin matrix with or
without growth factors.

Methods: A systematic review of the literature was performed to evaluate the use of fibrin matrices with or without
growth factors for the management of chronic venous ulcers in lower limbs. Article searches were performed in
MEDLINE, EMBASE, COCHRANE, LILACS and ongoing clinical trials at ClinicalTrial.gov.

Results: The search in MEDLINE and EMBASE identified three articles; one was a pilot study evaluating the use of
fibrin matrix and autologous growth factors that included patients with chronic ulcers of different etiology. The second
article was a description of the product used in the previous study, and the third consisted of a series case reports of
patient treated with cultured keratinocytes in a fibrin matrix. A COCHRANE searched resulted in one study assessing
the cost effectiveness of using different fibrin matrices. The search in ClinicalTrial.gov and LILACS did not result in any
findings.

Conclusion: The study did not provide a conclusive evidence for the use of fibrin matrices in patients with venous leg
ulcers.

Keywords: Venous ulcers, legs, fibrin matrix, growth factors

© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0
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