Page 69 - Read Online
P. 69

Page 10 of 12            Tanner et al. Plast Aesthet Res 2023;10:11  https://dx.doi.org/10.20517/2347-9264.2022.95

               the gap between the literature on the peripheral nervous system and TMR.


               CONCLUSION
               In conclusion, TMR can be successful in treating neuromata and postamputation pain in amputees. Given
               the increasing use of TMR for amputees, further research should be done into the basic science of TMR. A
               better understanding of the mechanism of peripheral nerve injury can help surgeons improve treatments for
               amputation patients and develop new surgical techniques to prevent pain. Comprehensive, evidence-based
               knowledge of TMR has the potential to vastly improve the outcomes, function, and quality of life of
               amputees.


               DECLARATIONS
               Authors’ contributions
               Made substantial contributions to the conception and design of the study, implementation of the research
               and interpretation: Tanner N, Ayalon O
               Took the lead in writing the manuscript with input and critical feedback: Ayalon O, Tanner N
               Discussed the findings and contributed to the final manuscript: Tanner N, Ayalon O

               Availability of data and materials
               Not applicable.

               Financial support and sponsorship
               None.

               Conflicts of interest
               Both authors have declared that there are no conflicts of interest.

               Ethical approval and consent to participate
               Not applicable.


               Consent for publication
               Not applicable.


               Copyright
               © The Author(s) 2023.


               REFERENCES
               1.       Limb Loss in the U.S.A. Amputee coalition. Available from: https://www.amputee-coalition.org/wp-content/uploads/2020/03/LLAM-
                   Infographic-2020.pdf [Last accessed on 30 Mar 2023].
               2.       Hanley MA, Ehde DM, Jensen M, Czerniecki J, Smith DG, Robinson LR. Chronic pain associated with upper-limb loss. Am J Phys
                   Med Rehabil 2009;88:742-51-quiz 752, 779.  DOI  PubMed  PMC
               3.       Ephraim PL, Wegener ST, MacKenzie EJ, Dillingham TR, Pezzin LE. Phantom pain, residual limb pain, and back pain in amputees:
                   results of a national survey. Arch Phys Med Rehabil 2005;86:1910-9.  DOI  PubMed
               4.       Dumanian GA, Potter BK, Mioton LM, et al. Targeted muscle reinnervation treats neuroma and phantom pain in major limb amputees:
                   a randomized clinical trial. Ann Surg 2019;270:238-46.  DOI  PubMed
               5.       Valerio IL, Dumanian GA, Jordan SW, et al. Preemptive treatment of phantom and residual limb pain with targeted muscle
                   reinnervation at the time of major limb amputation. J Am Coll Surg 2019;228:217-26.  DOI  PubMed
               6.       Sheehan TP, Gondo GC. Impact of limb loss in the United States. Phys Med Rehabil Clin N Am 2014;25:9-28.  DOI  PubMed
               7.       Woo SL, Kung TA, Brown DL, Leonard JA, Kelly BM, Cederna PS. Regenerative peripheral nerve interfaces for the treatment of
                   postamputation neuroma pain: a pilot study. Plast Reconstr Surg Glob Open 2016;4:e1038.  DOI  PubMed  PMC
               8.       Cheesborough JE, Souza JM, Dumanian GA, Bueno RA Jr. Targeted muscle reinnervation in the initial management of traumatic
   64   65   66   67   68   69   70   71   72   73   74