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carefully analyzed according to eligibility criteria for future Subsequently, a comprehensive and careful reading of the
data extraction. From each study included in the review the full-text of selected articles was carried out (6 articles).
following information was extracted: first author, year of Finally, only 4 articles were included for final data extraction
publication, study design, demographic data (age-range), [Figure 1]. Due the heterogeneity of analyzed studies a
number of subjects, tumor type, tumor site, tumor stage, qualitative synthesis of the data was performed.
margin identification, resection margin, surgical instrument
used for resection, measuring instrument, pre-resection Study characteristics
measurement, measuring time pre-post resection, mean The characteristics of the studies included in this review
shrinkage pre-post resection, measurement by stage and are showed in Tables 1 and 2. One prospective study, one
measurement by site. retrospective study and other two articles without a clear
definition of the type of study design were included. The
RESULTS number of participants in the studies ranged from 35 to 95,
and the average age was 59.32 years.
Literature search Three articles studied the discrepancy between “in
The initial search strategy yielded a total of 107 articles from situ” margins and “histopathologic” margins in patients
Pubmed database, 9 articles obtained from related citations underwent surgery for oral SCC, while one study analyzed
of Pubmed and 287 articles from hand- searching. In the first the effect of tissue shrinkage on surgical margins of resection
step, titles and abstracts of articles obtained in the strategy in patients operated for lip SCC. In all analyzed studies, the
search were reviewed for elimination of irrelevant articles appropriate surgical margin of resection was defined as that
(376 articles). In the second step, those articles related with margin located 1 cm from the tumor border; likewise, the
PICO question were analyzed for eligibility (27 articles). resection margin was identified by mean of marking ink in

Figure 1: Flow chart (screening and selection process) used for the articles included in this review
152 Plast Aesthet Res || Volume 3 || May 25, 2016