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Topic: Biomaterials for Plastic and Aesthetic Surgery

An update review on recent skin fillers

Li-Ying Cheng , Xiao-Ming Sun , Meng-Yao Tang , Rong Jin , Wen-Guo Cui ,
1
1
1
1
2
Yu-Guang Zhang 1
1 Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of
Medicine, Shanghai 200011, China.
2 Orthopedic Institute, Soochow University, Suzhou 215006, Jiangsu, China.
Address for correspondence: Dr. Yu-Guang Zhang, Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital,
Shanghai Jiao Tong University, School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, China. E-mail: zhangyg18@126.com

ABSTRACT
Facial rejuvenation has changed over the last decade, evolving from the rhytidectomy to an
approach that focuses on revolumization, due to a more complete understanding of the changes
to bone and soft tissue that occur with the aging face. Soft tissue augmentation using various
injectable filler agents has gained popularity due to their nonsurgical, non-invasive procedures,
instant cosmetic outcomes and limited recovery time. The skin filler market is booming and
the variety of available skin fillers is increasing, providing the plastic surgeons many choices.
Nonpermenant, biodegradable, resorbable agents may induce little complications, but they
will normally disappear soon after injection. Semipermenant, biodegradable, biostimulary,
nonresorbable fillers may induce a bit more complications, but they will normally disappear
spontaneously in a few months. Permanent, nonresorbable fillers usually give rise to severe
complications or reactions which may not disappear spontaneous. They may appear several
years after the injection, and treatment is often insufficient. Unfortunately, the ideal filler with
lasting effect but without any complication has not been discovered yet. In this review, we give
an update on currently available skin filler agents, and what is new in recent 5 years.

Key words:
Skin fillers; revolumization; biodegradable; biostimulory; nonresorbable; bovine collagen;
hyaluronic acid; polyacrylamide

INTRODUCTION and effective filler injection has come. Deep-volume
increase, combinational approaches, natural looking
The past decade has seen an evolution in the filler market outcomes, and safety measures are the most important
for meaningful volume restoration in the aging face. considerations for filler use.
There are now over 35 major filler product companies
[1]
worldwide. In 2014, there were 2.3 million soft-tissue Skin fillers on the market today are categorized into
filler procedures in the United States, an increase of transitory biodegradable or resorbable within months
3% from 2013. The days of treating a nasolabial fold and years respectively, and permanent or nonresorbable
[2]
with single skin filler injection is gone, and a new era of fillers. Biodegradable agents can be divided into
more sophisticated approach of thoughtful, restrained, This is an open access article distributed under the terms of the Creative Commons
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http://parjournal.net For reprints contact: service@oaepublish.com
How to cite this article: Cheng LY, Sun XM, Tang MY, Jin R, Cui
WG, Zhang YG. An update review on recent skin fillers. Plast Aesthet
DOI: Res 2016;3:92-9.
10.20517/2347-9264.2015.124.
Received: 29-11-2015; Accepted: 09-03-2016
92 © 2016 Plastic and Aesthetic Research | Published by OAE Publishing Inc.