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efficient to use than BMSCs. These characteristics, CONCLUSION
coupled with the observation that there is no significant
difference between ASCs and BMSCs in facilitating Sensory and motor regeneration are major hurdles that
nerve regeneration, points to ASCs as being a more must be addressed to realize the fullest potential of VCA.
efficient option in stem cell‑based enhancement of nerve Advances continue to be made in peripheral nerve repair, and
regeneration. [65] these results must be explored in the context of transplant
surgery. Results in post‑VCA functional outcomes continue to
While the transplantation of Schwann cells into nerve improve, and soon, we can expect more consistent, reliable,
conduits has demonstrated increased regenerative and faster recovery of sensation and motor control to donor
[66]
potential, ASCs have also been demonstrated to have tissues. Exciting advancements in the area of ASC‑enhanced
a pro‑regenerative effect on growing axons. [67‑70] The nerve regeneration may offer a promising frontier towards
mechanism for this effect is in the differentiation of ASCs addressing this challenging question.
into Schwann cell‑like phenotypes in the context of nerve
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