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Page 12 of 15             Inchauste. Plast Aesthet Res 2023;10:27  https://dx.doi.org/10.20517/2347-9264.2022.139

               accomplished [16,66,68] . TPA is directly administered to the flap during flap salvage and has not demonstrated
               an increased risk of hematoma to either the flap or abdomen [28,48] . Flap salvage rate with the use of
               thrombolytics is lower, likely due to the increased thrombus burden that necessitated thrombolytic
                      [48]
               therapy . When salvaging a failing flap with significant clot burden, this is typically the last maneuver that
               can be done to void the flap of thrombus and reestablish perfusion.


               CONCLUSION
               Reconstructive autologous free flap breast reconstruction is a growing field with innovation, technological
               advancements, broader application, and increased availability to patients. Core principles of microsurgery
               such as meticulous dissection, atraumatic vessel handling, adequate magnification, appropriate recipient
               vessel selection, and tension-free anastomosis with direct intima to intima contact are key maneuvers for a
               successful microsurgical reconstruction. Identification and correction of inflow or outflow problems
               intraoperatively can prevent thrombus formation and flap compromise. If vascular compromise is suspected
               postoperatively, immediate return to the operating room for exploration is a must. Every microsurgeon
               must develop an algorithm to first diagnose the problem, then implement a stepwise plan to execute the
               maneuvers needed to reestablish perfusion to the flap in order to successfully salvage a failing flap.

               DECLARATIONS
               Authors’ contributions
               The author contributed solely to the article.

               Availability of data and materials
               Not applicable.


               Financial support and sponsorship
               None.


               Conflicts of interest
               The author declared that there are no conflicts of interest.


               Ethical approval and consent to participate
               The University of Washington Medical Center stated that the study does not need to complete an IRB since
               the figures are examples of surgical techniques similar to a case report. The author states that there is no
               ethical concern since the photos do not include any PHI or patient identifiers such as a face or unique
               tattoos.


               Consent for publication
               All patients gave consent for participation and publication.

               Copyright
               © The Author(s) 2023.


               REFERENCES
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               2.       Holmström H. The free abdominoplasty flap and its use in breast reconstruction. An experimental study and clinical case report. Scand
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               3.       Surgery. National plastic surgery statistics. Available from: https://www.plasticsurgery.org/documents/News/Statistics/2020/plastic-
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