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Jaswant et al. One Health Implement Res 2024;4:15-37 One Health &
DOI: 10.20517/ohir.2023.61
Implementation Research

Systematic Review Open Access

Viral sequencing to inform the global elimination of
dog-mediated rabies - a systematic review

1,6
Gurdeep Jaswant 1,2,3,4,# , Criselda T. Bautista 2,5,# , Brian Ogoti , Joel Changalucha 4,7 , Julius O.
Oyugi 1,8 , Kathryn Campbell 2 , Mumbua Mutunga 1,6 , S.M. Thumbi 1,6,7,8,9,10,# , Katie Hampson 2,# ,
Kirstyn Brunker 2,#
1
Faculty of Health Sciences, Institute of Tropical and Infectious Diseases, University of Nairobi, Nairobi 00202, Kenya.
2
School of Biodiversity, One Health & Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of
Glasgow, Glasgow G12 8QQ, Scotland, UK.
3
Food Biotechnology and Microbiology, Tanzania Industrial Research Development Organization, Dar es Salaam 14111, Tanzania.
4
Environmental Health and Ecological Sciences, Ifakara Health Institute, Dar es Salaam Plot 463, Tanzania.
5
Research Institute for Tropical Medicine, Muntinlupa City, Metro Manila 1781, Philippines.
6
Faculty of Health Sciences, Center for Epidemiological Modelling and Analysis, University of Nairobi, Nairobi 00202, Kenya.
7
College of Veterinary Medicine & Biomedical Science, Sokoine University of Agriculture, Morogoro 67804, Tanzania.
8
Department of Medical Microbiology, Faculty of Health Sciences, University of Nairobi, Nairobi 00202, Kenya.
9
Institute of Immunology & Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL,
Scotland, UK.
10
Paul G Allen School for Global Health, Washington State University, Pullman, WA 99164, USA.
#
Authors contributed equally.
Correspondence to: Dr. Kirstyn Brunker, Graham Kerr building, School of Biodiversity, One Health & Veterinary Medicine,
College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. E-mail:
kirstyn.brunker@glasgow.ac.uk
How to cite this article: Jaswant G, Bautista CT, Ogoti B, Changalucha J, Oyugi JO, Campbell K, Mutunga M, Thumbi SM,
Hampson K, Brunker K. Viral sequencing to inform the global elimination of dog-mediated rabies - a systematic review. One
Health Implement Res 2024;4:15-37. https://dx.doi.org/10.20517/ohir.2023.61
Received: 5 Dec 2023 First Decision: 2 Apr 2024 Revised: 13 May 2024 Accepted: 22 May 2024 Published: 31 May 2024
Academic Editor: Jose M. Martin-Moreno Copy Editor: Pei-Yun Wang Production Editor: Pei-Yun Wang

Abstract
Background: Rabies is a fatal zoonotic disease, present in almost 150 countries. The “Zero by 30” initiative aims to
eliminate human deaths from dog-mediated rabies globally by 2030. This systematic review investigates how viral
sequencing can contribute to achieving the “Zero by 30” goal by improving understanding of viral circulation and
the impact of rabies control measures.

Methods: A comprehensive search of bibliographic databases was conducted focusing on research on rabies from
regions with endemic dog-mediated rabies published between 2000 and 2023, adhering to Preferred Reporting

© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0
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adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as
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