Page 32 - Read Online
P. 32

Page 210                      Walker. Neuroimmunol Neuroinflammation 2020;7:194-214  I  http://dx.doi.org/10.20517/2347-8659.2020.09



               DECLARATIONS
               Acknowledgments
               The author thanks the support from the Banner Sun Health Research Institute (BSHRI) and their Brain
               and Body Donation Program (BBDP) for providing high quality brain samples for studies on human brain
               microglia over the last 20 years that have allowed him to make these comments and observations.

               Authors’ contributions
               Conceived and wrote this article, took responsibility for the ideas presented: Walker DG

               Availability of data and materials
               Not applicable

               Financial support and sponsorship
               None.

               Conflicts of interest
               The author declared that there are no conflicts of interest.

               Ethical approval and consent to participate
               The author’s publications that are referenced in this review article utilized human brain tissue samples
               provided by the Brain Bank, BSHRI. Most of the studies referenced refer to anonymous tissue studies
               carried out in the USA, which are considered non-human subject research under U.S. federal regulations.
               Some of these studies were completed in Japan using the same tissue samples that had been transferred to
               Japan with the author. Tissue studies carried out in Japan were approved by the Shiga University of Medical
               Science Ethical Committee (Certificate No. 29-114).


               Consent for publication
               Not applicable.


               Copyright
               © The Author(s) 2020.

               REFERENCES
               1.   Ulep MG, Saraon SK, McLea S. Alzheimer disease. J Nurse Pract 2018;14:129-35.
               2.   Simon DK, Tanner CM, Brundin P. Parkinson disease epidemiology, Pathology, genetics, and pathophysiology. Clin Geriatr Med
                   2020;36:1-12.
               3.   DeTure MA, Dickson DW. The neuropathological diagnosis of Alzheimer’s disease. Mol Neurodegener 2019;14:32.
               4.   Kim WS, Kagedal K, Halliday GM. Alpha-synuclein biology in Lewy body diseases. Alzheimers Res Ther 2014;6:73.
               5.   Heppner FL, Ransohoff RM, Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci 2015;16:358-
                   72.
               6.   Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med 2017;23:1018-27.
               7.   Wang Q, Liu Y, Zhou J. Neuroinflammation in Parkinson’s disease and its potential as therapeutic target. Transl Neurodegener 2015;4:19.
               8.   in t’ Veld BA, Ruitenberg A, Hofman A, Launer LJ, van Duijn CM, et al. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s
                   disease. N Engl J Med 2001;345:1515-21.
               9.   Wang J, Tan L, Wang HF, Tan CC, Meng XF, et al. Anti-inflammatory drugs and risk of Alzheimer’s disease: an updated systematic
                   review and meta-analysis. J Alzheimers Dis 2015;44:385-96.
               10.   Chew G, Petretto E. Transcriptional networks of microglia in Alzheimer’s disease and insights into pathogenesis. Genes (Basel) 2019;10.
               11.   Mathys H, Adaikkan C, Gao F, Young JZ, Manet E, et al. Temporal tracking of microglia activation in neurodegeneration at single-cell
                   resolution. Cell Rep 2017;21:366-80.
               12.   Patir A, Shih B, McColl BW, Freeman TC. A core transcriptional signature of human microglia: derivation and utility in describing
                   region-dependent alterations associated with Alzheimer’s disease. Glia 2019;67:1240-53.
   27   28   29   30   31   32   33   34   35   36   37