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Cencioni. Neuroimmunol Neuroinflammation 2020;7:277-90  I  http://dx.doi.org/10.20517/2347-8659.2020.18                Page 287

               Financial support and sponsorship
               This work was supported by Fondazione Italiana Sclerosi Multipla (ref. 2015/R/16 to PM), by Elena Pecci
               research project and Fondazione Careggi Onlus.

               Conflicts of interest
               The author declared that there are no conflicts of interest.

               Ethical approval and consent to participate
               Not applicable.


               Consent for publication
               Not applicable.

               Copyright
               © The Author(s) 2020.


               REFERENCES
               1.   Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJ, Suresh M, et al. Viral immune evasion due to persistence of activated T cells
                   without effector function. J Exp Med 1998;188:2205-13.
               2.   Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R. Viral persistence alters CD8 T-cell immunodominance and tissue
                   distribution and results in distinct stages of functional impairment. J Virol 2003;77:4911-27.
               3.   Battegay M, Moskophidis D, Rahemtulla A, Hengartner H, Mak TW, et al. Enhanced establishment of a virus carrier state in adult CD4+
                   T-cell-deficient mice. J Virol 1994;68:4700-4.
               4.   Sun JC, Williams MA, Bevan MJ. CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute
                   infection. Nat Immunol 2004;5:927-33.
               5.   Janssen EM, Lemmens EE, Wolfe T, Christen U, von Herrath MG, et al. CD4+ T cells are required for secondary expansion and memory
                   in CD8+ T lymphocytes. Nature 2003;421:852-6.
               6.   Day CL, Walker BD. Progress in defining CD4 helper cell responses in chronic viral infections. J Exp Med 2003;198:1773-7.
               7.   Urbani S, Amadei B, Fisicaro P, Tola D, Orlandini A, et al. Outcome of acute hepatitis C is related to virus-specific CD4 function and
                   maturation of antiviral memory CD8 responses. Hepatology 2006;44:126-39.
               8.   Matloubian M, Concepcion RJ, Ahmed R. CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral
                   infection. J Virol 1994;68:8056-63.
               9.   Fuller MJ, Zajac AJ. Ablation of CD8 and CD4 T cell responses by high viral loads. J Immunol 2003;170:477-86.
               10.  Moskophidis D, Lechner F, Pircher H, Zinkernagel RM. Virus persistence in acutely infected immunocompetent mice by exhaustion of
                   antiviral cytotoxic effector T cells. Nature 1993;362:758-61.
               11.  Iyasere C, Tilton JC, Johnson AJ, Younes S, Yassine-Diab B, et al. Diminished proliferation of human immunodeficiency virus-specific
                   CD4+ T cells is associated with diminished interleukin-2 (IL-2) production and is recovered by exogenous IL-2. J Virol 2003;77:10900-9.
               12.  Aubert RD, Kamphorst AO, Sarkar S, Vezys V, Ha SJ, et al. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during
                   chronic viral infection. Proc Natl Acad Sci U S A 2011;108:21182-7.
               13.  West EE, Youngblood B, Tan WG, Jin HT, Araki K, et al. Tight regulation of memory CD8(+) T cells limits their effectiveness during
                   sustained high viral load. Immunity 2011;35:285-98.
               14.  do Canto LM, Farias TD, Medeiros MD, Coêlho CC, Sereia AF, et al. Association of PDCD1 polymorphism to systemic lupus
                   erythematosus and rheumatoid arthritis susceptibility. Rev Bras Reumatol Engl Ed 2016;56:483-9.
               15.  Moser JM, Altman JD, Lukacher AE. Antiviral CD8+ T cell responses in neonatal mice: susceptibility to polyoma virus-induced tumors
                   is associated with lack of cytotoxic function by viral antigen-specific T cells. J Exp Med 2001;193:595-606.
               16.  Krebs P, Scandella E, Odermatt B, Ludewig B. Rapid functional exhaustion and deletion of CTL following immunization with
                   recombinant adenovirus. J Immunol 2005;174:4559-66.
               17.  Kostense S, Vandenberghe K, Joling J, Van Baarle D, Nanlohy N, et al. Persistent numbers of tetramer+ CD8(+) T cells, but loss of
                   interferon-gamma+ HIV-specific T cells during progression to AIDS. Blood 2002;99:2505-11.
               18.  Gruener NH, Lechner F, Jung MC, Diepolder H, Gerlach T, et al. Sustained dysfunction of antiviral CD8+ T lymphocytes after infection
                   with hepatitis C virus. J Virol 2001;75:5550-8.
               19.  Urbani S, Boni C, Missale G, Elia G, Cavallo C, et al. Virus-specific CD8+ lymphocytes share the same effector-memory phenotype but
                   exhibit functional differences in acute hepatitis B and C. J Virol 2002;76:12423-34.
               20.  Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, et al. Restoring function in exhausted CD8 T cells during chronic viral infection.
                   Nature 2006;439:682-7.
               21.  Ajona D, Ortiz-Espinosa S, Lozano T, Exposito F, Calvo A, et al. Short-term starvation reduces IGF-1 levels to sensitize lung tumors to
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