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Zarei. Neuroimmunol Neuroinflammation 2018;5:13 Neuroimmunology
DOI: 10.20517/2347-8659.2018.02 and Neuroinflammation

Original Article Open Access

Precentral gyrus abnormal connectivity in male and
female patients with schizophrenia

Mahdi Zarei

Department of Bioengineering, School of Pharmacy, University of California San Francisco, San Francisco, CA 94158, USA.
Correspondence to: Dr. Mahdi Zarei, Department of Bioengineering, School of Pharmacy, University of California San Francisco,
1550 4th Street, Bldg 19B, San Francisco, CA 94158, USA. E-mail: mahdi.zarei@ucsf.edu, mehdi.nn@gmail.com

How to cite this article: Zarei M. Precentral gyrus abnormal connectivity in male and female patients with schizophrenia.
Neuroimmunol Neuroinflammation 2018;5:13. http://dx.doi.org/10.20517/2347-8659.2018.02

Received: 8 Jan 2018 First Decision: 8 Feb 2018 Revised: 27 Mar 2018 Accepted: 29 Mar 2018 Published: 23 Apr 2018
Science Editor: Athanassios P. Kyritsis Copy Editor: Guang-Zhe Zhu Production Editor: Cai-Hong Wang

Abstract
Aim: Dysfunction of the precentral gyrus plays a role in the impairments of voluntary movement associated with
schizophrenia and it has significantly reduced functional activity in patients with schizophrenia. The aim of this study
was to demonstrate the precentral gyrus alteration and its abnormal connectivity in schizophrenia.

Methods: The region of interest-based analysis method was used to investigate the precentral gyrus connectivity
alteration in schizophrenia. The resting-state functional magnetic resonance imaging data of healthy control subjects
and patients with schizophrenia (Centers of Biomedical Research Excellence data set) was used to examine the aberrant
functional brain connectome in schizophrenia. This data set contains raw anatomical and functional magnetic resonance
data from 72 patients with schizophrenia and 75 healthy controls, ranging in age from 18 to 65 years old.

Results: Our results show precentral gyrus has abnormal communication with thalamus, hippocampus, parahippocampal
gyrus, posterior division of supramarginal gyrus and medial prefrontal cortex (pFDR = 0.05). This information is
expected to provide a better understanding of altered functional connectivity of the precentral gyrus in the male and
female patients with schizophrenia.

Conclusion: Collectively, these findings support the hypothesis that precentral gyrus has an abnormal connectivity in
schizophrenia and this alteration is not the same in the male and female patients with schizophrenia.

Keywords: Schizophrenia, functional magnetic resonance imaging, functional connectivity, resting-state, precentral
gyrus

© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0
International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use,
sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long
as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
and indicate if changes were made.

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