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Neuroimmunol Neuroinflammation 2018;5:37 I http://dx.doi.org/10.20517/2347-8659.2018.45 Page 5 of 9

suspected focal cortical dysplasia over TPO region in dominant hemisphere. Eight patients with > 75%
seizure reduction with etiologies: Leigh’s disease (complex I&IV respiratory chain enzyme deficiency), 2
suspected neuro-metabolic disease, post-HIE epilepsy, familial HLH, SSADH deficiency, post-influenza
encephalopathy epilepsy, focal epilepsy. Five patients with 50%-75% with etiologies: Ohtahara’s syndrome,
post-HSV encephalitis, extensive right side fronto-central focal cortical dysplasia, 2 symptomatic generalised
epilepsy. Five patients with seizure no change with etiologies: STXBP1 mutation, LGS, symptomatic
epilepsy, 2 extensive focal/ hemi-cortical dysplasia, the latter two underwent epilepsy surgery with seizure
improvement.

Conclusion: In view of better seizure outcome in surgery when compared with VNS and dietary treatment,
refractory epilepsy patients with underlying lesion should consider epilepsy surgery. On the contrary, those
with underlying metabolic or genetic disease and those with no definite focus or diffuse lesions should be
considered for ketogenic diet or vagal nerve stimulator implantation.

6. Reminiscence therapy on enhancing cognitive and improving brain wave in mild cognitive
impairment

Santi Yuliani, Anita Budijanto, Dyah Wiratmi, Farida Hermani

Prof. Dr. Soerojo Magelang Psychiatric Hospital

Aim: The aims of this research are to measure the effectiveness of reminiscence therapy on enhancing
cognitive function and changes in brain waves in vascular MCI compared with MCI.

Methods: We used quasi-experimental research with pre-test and post-test study design, and statistical
2
analysis F-test and c -test, with a = 5%. Subjects were divided into two groups, 16 in the MCI group and 16
in the MCI vascular group. Pre-tests were conducted prior to MOCA-INA and subjects’ brain waves were
examined with qEEG and brain mapping. Reminiscence therapies were conducted for 3 months for both
groups and continued with the post-test.

Results: The result showed significant progress on cognitive enhancement with P value 0.0002 (P value <
0.05) both in the MCI group and MCI vascular group. The brain wave also showed some changes particularly
in the MCI group; there were some significant changes in decreasing slow wave and increasing fast wave.

Conclusion: We can conclude that reminiscence therapy is effective on enhancing cognitive and improving
brain wave for mild cognitive impairment.

7. Serum serotonin, a good indicator of insomnia in elderly with depression

Retnaningsih

Diponegoro University/Dr. Kariadi General Hospital

Aim: To evaluate the predictive value of serum serotonin for insomnia in elderly people.