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Neuroimmunol Neuroinflammation 2018;5:37 I http://dx.doi.org/10.20517/2347-8659.2018.45 Page 7 of 9

9. Role of S100β protein as a prognostic factor in patient with acute intracerebral
hemorrhage

2
2
Poppy Kristina Sasmita , Ismail Setyopranoto , Samekto Wibowo , Ahmad Hamim Sadewa 3
1
1 Atma Jaya Catholic University of Indonesia
2 Universitas Gadjah Mada - Dr. Sardjito General Hospital
3 Universitas Gadjah Mada

S100β protein has shown its potential as biomarker of brain injury, however its efficacy is less known in
intracerebral hemorrhage (ICH) cases. Patients with ICH, who have same hematoma volume at the same
location and received similar appropriate treatments, could have different neurological deficits and different
prognoses. It is believed that many damages occurring in the subacute period were due to a complex
pathophysiology pathway that still needs to be proven. There were 46 intracerebral hemorrhagic patients
who entered the hospital consecutively during the period of August to December. CT scans were performed
and met the inclusion and exclusion criteria. Neurological deficits as ascertained with National Institute
of Health Stroke Scale (NIHSS). Blood samples were taken at admission to the hospital and 7th day of
onset. There were 25 men (54.3%) with a median age of 56 (31-76) years. The most important risk factor was
hypertension (78.3%). Median serum S100B levels in the ICH patients were significantly higher than those
in normal individuals [22.70 (19.06-445.99) vs. 16.3 (15.58-23.79) pg/mL, P < 0.001)] and serum S100β protein
level was significantly higher in the non-survival group than in the survival group [25.86 (19.78-445.99) vs.
21.325 (19.06-63.28) pg/mL, P = 0.032]. Serum S100β protein levels correlated significantly with NIHSS (r
= 0.418; P = 0.004). Area Under Curve (AUC) of S100β was 0.839 ± 0.103 (95% CI, 0.638-1.000), cutoff level
was 28.505 pg/mL with 80% sensitivity and 87.8% specificity (P = 0.014). S100β protein levels correlated
significantly with mortality within 1 week (P = 0.032). High levels of S100β are present in the peripheral
blood of patients with ICH and seem to correlate with neurological deficit and mortality within 1 week.
Serum S100β level may be useful as marker for evaluating the prognosis of ICH.

10. Evaluation of language dysfunction and psychological state in stroke patients

Famida Firdose, Parvez Khandakar Ahmed, Hariprakash Chakravarthy

ZH Sikder Institute of Neurosciences, ZH Sikder Women’s Medical College Hospital

Aim: Evaluate multiple faculties of language function in about 116 patients with stroke in the past 8 months.

Methods: It’s an observational study that evaluated all the stroke patients who were treated at ZH Sikder
Institute of Neurosciences. Excluded the patients with other comorbidity that caused dementia and language
dysfunction viz, PD, Cortico basal degeneration, Alzheimer’s dementia.

Results: Most of the respondents were males (90%) ranging from 35 to 85 years. Most respondents had
changeable risk factors. Significant language disturbance was seen in 30% of the patients and over 70% of the
patients had minor impairment in language function. Emotional disturbance was seen in over 90% of these
patients.

Conclusion: Language dysfunction is more common in stroke than we traditionally expect. Emotional