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Cui et al. Neuroimmunol Neuroinflammation 2017;4:20-3 Neuroimmunology and
DOI: 10.20517/2347-8659.2016.14
Neuroinflammation

www.nnjournal.net
Guidelines Open Access

Treatment guidelines of chronic inflammatory

demyelinating polyneuropathy in China

Li-Ying Cui , Chuan-Qiang Pu , Xue-Qiang Hu 3
2
1
1 Department of Neurology, Peking Union Medical Hospital, Chinese Academy of Medical Science, Beijing 100730, China.
2 Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
3 Department of Neurology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong, China.
Correspondence to: Dr. Li-Ying Cui, Department of Neurology, Peking Union Medical Hospital, Chinese Academy of Medical Science, Beijing
100730, China. E-mail: pumchcly@yahoo.com.cn
How to cite this article: Cui LY, Pu CQ, Hu XQ. Treatment guidelines of chronic inflammatory demyelinating polyneuropathy in China.
Neuroimmunol Neuroinflammation 2017;4:20-3.

Article history: Received: 25-03-2016 Accepted: 30-11-2016 Published: 20-02-2017

Chronic inflammatory demyelinating CLINICAL SYMPTOMS AND CLASSIFICATION
polyradiculoneuropathy, or chronic inflammatory
demyelinating polyneuropathy (CIDP) is an acquired Classical CIDP
immune-mediated inflammatory disorder at the (1) This will onset at different age groups, and
peripheral nervous system, in which the progression commonly found in 40-60 years old. There is no
is chronic and also remission relapse. In most cases, gender difference in onset rate; (2) no clear history
it is also associated with cerebrospinal fluid (CSF) of infection; (3) classifications: this can be classified
protein-cell separation. Electrophysiologically, the into two sub-types: chronic progressive and remission
peripheral nerve conduction velocity decreases, blocks relapsing. For young patients, there are more cases
of remission relapsing subtype, who will have a better
and characterized as discrete abnormal waveform. prognosis. For elderly patients, there are more cases
Pathologically, there is also multifocal demyelination of chronic progressive sub-type, who will have a worse
of myelinated fibers, nerve endometrial edema, prognosis; (4) clinical symptoms: the symptoms onset
[2]
inflammatory cell infiltration, etc. chronically, which progress over eight weeks; but 16%
[3]
of the CIDP patients showed a subacute onset, the
CIDP can be classified as classical and variant types, symptoms of which progress rapidly and reaches to a
the latter of which is rare, including pure motor, pure peak in 4-8 weeks. Additionally, patients are sensitive to
sensory, distal acquired demyelinating symmetric glucocorticoid response. Patients are classified as CIDP
(DADS) neuropathy, multifocal acquired demyelinating tendency but not acute inflammatory demyelinating
sensory and motor (MADSAM, also known as Lewis- polyradiculoneurophy. CIDP symptoms confined to
Sumner syndrome) neuropathy, etc. [1] the peripheral nervous system, mainly including: (A)

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