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Polcyn et al. NSE in neural survival and death

Research-2017: M. Capone, A. Hossain, D. Matzelle 9. Cox A, Varma A, Banik N. Recent advances in the pharmacologic
Drafted the manuscript: R. Polcyn, A. Haque treatment of spinal cord injury. Metab Brain Dis 2015;30:473-82.
Edited the manuscript: D. Matzelle, N.L. Banik 10. Chakrabarti M, Haque A, Banik NL, Nagarkatti P, Nagarkatti M, Ray
Reviewed and approved the final version of the SK. Estrogen receptor agonists for attenuation of neuroinflammation
and neurodegeneration. Brain Res Bull 2014;109:22-31.
manuscript: All authors 11. Momeni HR. Role of calpain in apoptosis. Cell J 2011;13:65-72.
12. Zhang JM, An J. Cytokines, inflammation, and pain. Int Anesthesiol
Financial support and sponsorship Clin 2007;45:27-37.
This work was supported by grants from the National 13. Sun S, Chen D, Lin F, Chen M, Yu H, Hou L, Li C. Role of
Institutes of Health (R01 CA129560) and the South interleukin-4, the chemokine CCL3 and its receptor CCR5 in
Carolina Spinal Cord Injury Research Fund (SCIRF neuropathic pain. Mol Immunol 2016;77:184-92.
#2016 I-03), MUSC Center for Global Health Award, 14. Sun Y, Yang M, Tang H, Ma Z, Liang Y, Li Z. The over-production of
TNF-alpha via Toll-like receptor 4 in spinal dorsal horn contributes to
and the HCC-NCI Incentive Award to A. Haque, and the chronic postsurgical pain in rat. J Anesth 2015;29:734-40.
Ralph H. Johnson Veterans Administration Medical 15. Teixeira JM, de Oliveira-Fusaro MC, Parada CA, Tambeli CH.
Center, Charleston, SC (1I01BX002349-01) to N.L. Peripheral P2X7 receptor-induced mechanical hyperalgesia is mediated
Banik. by bradykinin. Neuroscience 2014;277:163-73.
16. Zhu X, Wei D, Chen O, Zhang Z, Xue J, Huang S, Zhu W, Wang Y.
Conflicts of interest Upregulation of CCL3/MIP-1alpha regulated by MAPKs and NF-
There are no conflicts of interest. kappaB mediates microglial inflammatory response in LPS-induced
brain injury. Acta Neurobiol Exp (Wars) 2016;76:304-17.
17. Liu C, Cui G, Zhu M, Kang X, Guo H. Neuroinflammation in
Patient consent Alzheimer’s disease: chemokines produced by astrocytes and
Not applicable. chemokine receptors. Int J Clin Exp Pathol 2014;7:8342-55.
18. van Weering HR, Boddeke HW, Vinet J, Brouwer N, de Haas AH, van
Ethics approval Rooijen N, Thomsen AR, Biber KP. CXCL10/CXCR3 signaling in glia
Not applicable. cells differentially affects NMDA-induced cell death in CA and DG
neurons of the mouse hippocampus. Hippocampus 2011;21:220-32.
19. Obermajer N, Doljak B, Jamnik P, Fonovic UP, Kos J. Cathepsin X
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