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Lu et al. Neuroimmunol Neuroinflammation 2017;4:145-51 Neuroimmunology and
DOI: 10.20517/2347-8659.2017.05
Neuroinflammation

www.nnjournal.net
Topic: Stroke Open Access

Relationship of cerebral microbleeds to

inflammatory marker levels

Qiao-Li Lu , Chen Li , Ying Song , Liang Wang , Zhi-Rong Jia 3
2
1
1
1
1 Department of Neurology, Tianjin 5th Center Hospital, Tianjin 300450, China.
2 Department of Neurosurgery, Tianjin 5th Center Hospital, Tianjin 300450, China.
3 Department of Neurology, Peking University First Hospital, Beijing 100034, China.
Correspondence to: Dr. Chen Li, Department of Neurology, Tianjin 5th Center Hospital, 41 Zhejiang Road, Tanggu, Tianjin 300450, China.
E-mail: lichenokk@163.com
How to cite this article: Lu QL, Li C, Song Y, Wang L, Jia ZR. Relation of cerebral microbleeds to inflammatory marker levels. Neuroimmunol
Neuroinflammation 2017;4:145-51.
Dr. Chen Li works in Department of Neurology, Tianjin 5th Center Hospital. She graduated from Tianjin Medical
University and got her Master of Medicine in July 2011, and she is skilled in the diagnosis and treatment of
cerebrovascular diseases, neuroimmune diseases and anxiety-depression diseases. She enjoys reading and writing
as well as looking after her daughter.

ABSTRACT

Article history: Aim: The purpose of this study is to investigate the incidence, distribution and risk factors
Received: 24-02-2017 of cerebral microbleeds (CMBs) and the relation between CMBs and inflammation in
Accepted: 10-05-2017 ischemic cerebrovascular disease. Methods: Two hundred and one patients without acute
Published: 08-08-2017 infarction or transient ischemic attack were enrolled. The presence and number of CMB
were assessed on susceptibility-weighted imaging. The traditional risk factors of CMB were
Key words: recorded. Levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and
Cerebral microbleed, matrix metalloproteinase-9 (MMP-9) were tested. Logistic regression analyses were used for
traditional risk factor, multiple-factor analysis of risk factors of CMB. Results: Of the 201 patients, 49 (24.38%)
inflammatory marker level, had CMB. Multivariate logistic regression analyses showed that the age, the prevalence of
susceptibility-weighted imaging hypertension, silent lacunar infarction, white matter lesion, Montreal Cognitive Assessment
Score, the using rate of antithrombotic drugs and levels of hs-CRP, IL-6, MMP-9 were the
risk factors for CMB. After adjustments for traditional risk factors, inflammatory marker
levels remained to be associated with CMBs. The adjusted odd ratios of hs-CRP, IL-6 and
MMP-9 were 1.745 (1.342-2.270), 1.223 (1.018-1.533) and 1.284 (1.082-1.423), respectively.
Furthermore, inflammatory marker levels were the risk factor for deep or infratentorial CMBs
and lobar CMBs. Conclusion: The age, prevalence of hypertension, silent lacunar infarction,
white matter lesion, MoCA Score, the using rate of antithrombotic drugs and serum hs-CRP,
IL-6, and MMP-9 levels were the independent risk factors for CMBs.

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