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Review

Necroptosis: a new link between cell death

and inflammation

Yuan-Hang Pan , Xun-Yuan Liu , Jia-Qiang Liu , Qian Liu , Yang Yang , Jia-Lei Yang , Xiu-Fen Zhang , Yin Wu ,
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Ya-Zhou Wang 1
1 Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, The Fourth
Military Medical University, Xi’an 710032, Shaanxi, China.
2 Health Care Division, Guard Bureau of Joint Staff, Beijing 100050, China.
3 Department of Neurology, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, Shaanxi, China.
4 Department of Pharmacy, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, Shaanxi, China.

Dr. Ya-Zhou Wang is an associate professor in the department of neurobiology of The Fourth Military Medical
University. He works on neural regeneration and stem cell biology. His papers revealed necroptosis in
secondary spinal cord injury and first proposed the concept of active neural stem cells in neuroscience field.

A B S T R AC T
Necroptosis is a type of newly identified cell death induced by apoptotic stimuli under conditions where apoptotic execution is
prevented. Studies over the past 10 years have revealed the molecular mechanism of necroptosis and challenged the old conception
that necrosis is un-programmed. Recently, more and more data have emerged suggesting a close association between necroptosis
and inflammation. In this review, the authors summarized the current knowledge of the mechanism of necroptosis, focusing on
tumour necrosis factor α induced necroptosis and the roles of necroptosis in regulating inflammation. In particular, we discussed the
occurrence of necroptosis and its relation with inflammation in neurological diseases hoping to provide new insight for the research
and treatment of neuroinflammatory disorders.
Key words: Necroptosis; inflammation; neurodegenerative diseases

INTRODUCTION when challenged by death signals. By ultrastructural
morphology, cell death is mainly classified as
Death is the most common ultimate fate of cells apoptosis, autophagy, or necrosis. During past
[1]
1
Corresponding Authors: Dr. Ya-Zhou Wang, Department decades, extensive studies have been performed on
of Neurobiology and Collaborative Innovation Center for apoptosis and autophagy, and have pictured very
Brain Science, School of Basic Medicine, The Fourth Military
Medical University, No. 169 Changle West Road, Xi’an elegant molecular mechanisms for apoptosis and
710032, Shaanxi, China. Email: yazhouw@fmmu.edu.cn autophagy. By utilizing these mechanisms, apoptosis
2 Dr. Yin Wu, Department of Pharmacy, Xijing Hospital, and autophagy can be finely regulated. Therefore, these
The Fourth Military Medical University, No. 169 Changle
West Road, Xi’an 710032, Shaanxi, China. Email: 2 types of cell death are regarded as “programmed cell
wuyin_2005@126.com
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How to cite this article: Pan YH, Liu XY, Liu JQ, Liu Q, Yang Y, Yang
JL, Zhang XF, Wu Y, Wang YZ. Necroptosis: a new link between
DOI: 10.20517/2347-8659.2015.59 cell death and inflammation. Neuroimmunol Neuroinflammation
2016;3:156-60.
Received: 28-12-2015; Accepted: 24-02-2016
156 © 2016 Neuroimmunology and Neuroinflammation | Published by OAE Publishing