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all of which are part of the classical symptomatology By improving our understanding of the mechanisms
of mood disorders, as well as fever. Cerebrovascular underlying such disorders, there is hope that in the
accidents are often associated with the onset of mood near future the development of novel therapeutic
disorders, mainly depression. As recently noted by approaches will result in better outcome.
Spalletta et al., the inflammatory process plays a
[8]
central role in the onset of poststroke depression Financial support and sponsorship
because several proinflammatory cytokines, produced Nil.
during stroke, such as IL‑1, IL‑6, TNF‑α or IL‑18 may
lead to its amplification, particularly in limbic areas. Conflicts of interest
This may cause widespread activation of indoleamine There are no conflicts of interest.
2,3‑dioxygenase and subsequently serotonin depletion
in paralimbic regions, such as the ventral lateral frontal REFERENCES
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194 Neuroimmunol Neuroinflammation | Volume 2 | Issue 4 | October 15, 2015 Neuroimmunol Neuroinflammation | Volume 2 | Issue 4 | October 15, 2015 PB