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50. Lightfield KL, Persson J, Brubaker SW, Witte CE, von Moltke J, brain-injured patients as biomarkers of functional outcome: clinical
Dunipace EA, Henry T, Sun YH, Cado D, Dietrich WF, Monack DM, article. J Neurosurg 2012;117:1119-25.
Tsolis RM, Vance RE. Critical function for Naip5 in inflammasome 64. Gris D, Ye Z, Iocca HA, Wen H, Craven RR, Gris P, Huang M,
activation by a conserved carboxy-terminal domain of flagellin. Nat Schneider M, Miller SD, Ting JP. NLRP3 plays a critical role in the
Immunol 2008;9:1171-8. development of experimental autoimmune encephalomyelitis by
51. Lee HM, Kang J, Lee SJ, Jo EK. Microglial activation of the NLRP3 mediating Th1 and Th17 responses. J Immunol 2010;185:974-81.
inflammasome by the priming signals derived from macrophages 65. Inoue M, Williams KL, Gunn MD, Shinohara ML. NLRP3
infected with mycobacteria. Glia 2013;61:441-52. inflammasome induces chemotactic immune cell migration to the
52. Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M Jr, CNS in experimental autoimmune encephalomyelitis. Proc Natl
Verma S. Inflammasome adaptor protein Apoptosis-associated Acad Sci U S A 2012;109:10480-5.
speck-like protein containing CARD (ASC) is critical for the immune 66. Lalor SJ, Dungan LS, Sutton CE, Basdeo SA, Fletcher JM, Mills KH.
response and survival in west Nile virus encephalitis. J Virol Caspase-1-processed cytokines IL-1beta and IL-18 promote
2013;87:3655-67. IL-17 production by gammadelta and CD4 T cells that mediate
53. Mori I, Hossain MJ, Takeda K, Okamura H, Imai Y, Kohsaka S, autoimmunity. J Immunol 2011;186:5738-48.
Kimura Y. Impaired microglial activation in the brain of 67. Mason JL, Suzuki K, Chaplin DD, Matsushima GK. Interleukin-1beta
IL-18-gene-disrupted mice after neurovirulent influenza A virus promotes repair of the CNS. J Neurosci 2001;21:7046-52.
infection. Virology 2001;287:163-70. 68. Jha S, Srivastava SY, Brickey WJ, Iocca H, Toews A, Morrison JP,
54. Sergerie Y, Rivest S, Boivin G. Tumor necrosis factor-alpha and Chen VS, Gris D, Matsushima GK, Ting JP. The inflammasome
interleukin-1 beta play a critical role in the resistance against lethal sensor, NLRP3, regulates CNS inflammation and demyelination
herpes simplex virus encephalitis. J Infect Dis 2007;196:853-60. via caspase-1 and interleukin-18. J Neurosci 2010;30:15811-20.
55. Chien H, Dix RD. Evidence for multiple cell death pathways during 69. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH.
development of experimental cytomegalovirus retinitis in mice with Mechanisms underlying inflammation in neurodegeneration. Cell
retrovirus-induced immunosuppression: apoptosis, necroptosis, and 2010;140:918-34.
pyroptosis. J Virol 2012;86:10961-78. 70. Codolo G, Plotegher N, Pozzobon T, Brucale M, Tessari I, Bubacco L,
56. Schielke GP, Yang GY, Shivers BD, Betz AL. Reduced ischemic de Bernard M. Triggering of inflammasome by aggregated
brain injury in interleukin-1 beta converting enzyme-deficient mice. a-synuclein, an inflammatory response in synucleinopathies. PLoS
J Cereb Blood Flow Metab 1998;18:180-5. One 2013;8:e55375.
57. Boutin H, LeFeuvre RA, Horai R, Asano M, Iwakura Y, Rothwell NJ. 71. Shi F, Yang L, Kouadir M, Yang Y, Wang J, Zhou X, Yin X,
Role of IL-1alpha and IL-1beta in ischemic brain damage. J Neurosci Zhao D. The NALP3 inflammasome is involved in neurotoxic
2001;21:5528-34. prion peptide-induced microglial activation. J Neuroinflammation
58. Zheng Y, Humphry M, Maguire JJ, Bennett MR, Clarke MC. 2012;9:73.
Intracellular interleukin-1 receptor 2 binding prevents cleavage 72. Craft JM, Watterson DM, Hirsch E, Van Eldik LJ. Interleukin
and activity of interleukin-1a, controlling necrosis-induced sterile 1 receptor antagonist knockout mice show enhanced
inflammation. Immunity 2013;38:285-95. microglial activation and neuronal damage induced by
59. Keller M, Rüegg A, Werner S, Beer HD. Active caspase-1 is a regulator intracerebroventricular infusion of human beta-amyloid.
of unconventional protein secretion. Cell 2008;132:818-31. J Neuroinflammation 2005;2:15.
60. de Rivero Vaccari JP, Lotocki G, Alonso OF, Bramlett HM, 73. Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE,
Dietrich WD, Keane RW. Therapeutic neutralization of the NLRP1 O’Banion MK. Sustained hippocampal IL-1 beta overexpression
inflammasome reduces the innate immune response and improves mediates chronic neuroinflammation and ameliorates Alzheimer
histopathology after traumatic brain injury. J Cereb Blood Flow plaque pathology. J Clin Invest 2007;117:1595-604.
Metab 2009;29:1251-61. 74. Meissner F, Molawi K, Zychlinsky A. Mutant superoxide dismutase
61. Abulafia DP, de Rivero Vaccari JP, Lozano JD, Lotocki G, Keane RW, 1-induced IL-1beta accelerates ALS pathogenesis. Proc Natl Acad
Dietrich WD. Inhibition of the inflammasome complex reduces the Sci U S A 2010;107:13046-50.
inflammatory response after thromboembolic stroke in mice. J Cereb
Blood Flow Metab 2009;29:534-44.
62. Frederick Lo C, Ning X, Gonzales C, Ozenberger BA. Induced Cite this article as: Xie Z, Zhao G. Pyroptosis and neurological diseases.
expression of death domain genes NALP1 and NALP5 following Neuroimmunol Neuroinflammation 2014;1(2):60-5.
neuronal injury. Biochem Biophys Res Commun 2008;366:664-9. Source of Support: Nil. Conflict of Interest: No.
63. Adamczak S, Dale G, de Rivero Vaccari JP, Bullock MR, Dietrich WD,
Keane RW. Inflammasome proteins in cerebrospinal fluid of Received: 11-07-2014; Accepted: 25-07-14

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