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also found that COR suppressed cell proliferation and early neonatal immune activation on depression‑like behaviors and
neurogenesis in the hippocampus, which can induce body weight in mice. Prog Neuropsychopharmacol Biol Psychiatry
depression-like behaviors. [19] Moreover, the important 7. 2013;43:55‑65.
Majidi‑Zolbanin J, Azarfarin M, Samadi H, Enayati M, Salari AA.
role of the hippocampus in depression-related behaviors Adolescent fluoxetine treatment decreases the effects of neonatal
has been shown in humans and rodents. [13] In line immune activation on anxiety‑like behavior in mice. Behav Brain
with this, we demonstrated that adolescent fluoxetine Res 2013;250:123‑32.
treatment reduced depression-like behaviors induced 8. Ellis S, Mouihate A, Pittman QJ. Neonatal programming of the rat
neuroimmune response: stimulus specific changes elicited by bacterial
by early neonatal infection in adult mice. It has and viral mimetics. J Physiol 2006;571:695‑701.
[6]
been reported that chronic fluoxetine and imipramine 9. Sominsky L, Fuller EA, Bondarenko E, Ong LK, Averell L,
treatments prevent the COR-induced reduction in Nalivaiko E, Dunkley PR, Dickson PW, Hodgson DM. Functional
programming of the autonomic nervous system by early
cell proliferation and activates neurogenesis in the life immune exposure: implications for anxiety. PLoS One
[19]
hippocampus. It seems reasonable to speculate that an 2013;8:e57700.
increase in depression-related behaviors or baseline COR 10. Enayati M, Solati J, Hosseini MH, Shahi HR, Saki G, Salari AA.
during adolescence following early neonatal immune Maternal infection during late pregnancy increases anxiety‑ and
depression‑like behaviors with increasing age in male offspring. Brain
activation may further suppress cell proliferation and Res Bull 2012;87:295‑302.
neurogenesis in the hippocampus in comparison with 11. Walker FR, March J, Hodgson DM. Endotoxin exposure in early
late neonatal immune activation, and these effects life alters the development of anxiety‑like behaviour in the Fischer
344 rat. Behav Brain Res 2004;154:63‑9.
can increase the severity of depression in adulthood. 12. Osborn DP, Fletcher AE, Smeeth L, Stirling S, Bulpitt CJ, Breeze E,
Moreover, we observed an interaction between treatment, Ng ES, Nunes M, Jones D, Tulloch A. Factors associated with
age, and the time of neonatal immune activation on depression in a representative sample of 14 217 people aged 75 and
depression-related behaviors in mice. Poly I:C at the dose over in the United Kingdom: results from the MRC trial of assessment
of 4 mg/kg during early postnatal brain development and management of older people in the community. Int J Geriatr
Psychiatry 2003;18:623‑30.
increased depression-related behaviors in adolescent 13. Krishnan V, Nestler EJ. The molecular neurobiology of depression.
mice, while the same dose during late neonatal phase Nature 2008;455:894‑902.
had no significant effect on depression in adolescent 14. Avishai‑Eliner S, Brunson KL, Sandman CA, Baram TZ. Stressed‑out,
or in (utero)? Trends Neurosci 2002;25:518‑24.
mice. Notably, the mice treated with Poly I:C at both 15. Konat GW, Lally BE, Toth AA, Salm AK. Peripheral immune
doses during early neonatal period exhibited elevated challenge with viral mimic during early postnatal period robustly
depression-related behaviors as adults, while only the enhances anxiety‑like behavior in young adult rats. Metab Brain Dis
dose of 4 mg/kg during the late neonatal phase increased 2011;26:237‑40.
depression in adult mice. Taken together, the findings 16. Amani M, Samadi H, Doosti MH, Azarfarin M, Bakhtiari A,
Majidi‑Zolbanin N, Mirza‑Rahimi M, Salari AA. Neonatal NMDA
of this study suggest that the effect of neonatal immune receptor blockade alters anxiety‑ and depression‑related behaviors
activation on depression-related behaviors in mice is in a sex‑dependent manner in mice. Neuropharmacology
dependent on the timing of the immune challenge and 2013;73:87‑97.
the dose of immunogen. 17. Ibi D, Nagai T, Kitahara Y, Mizoguchi H, Koike H, Shiraki A,
Takuma K, Kamei H, Noda Y, Nitta A, Nabeshima T, Yoneda Y,
Yamada K. Neonatal PolyI:C treatment in mice results in
REFERENCES schizophrenia‑like behavioral and neurochemical abnormalities in
adulthood. Neurosci Res 2009;64:297‑305.
1. Wu XQ, Li XF, Ye B, Popat N, Milligan SR, Lightman SL, O’Byrne KT. 18. Soriano RN, Branco LG. Reduced stress fever is accompanied by
Neonatal programming by immunological challenge: effects on increased glucocorticoids and reduced PGE2 in adult rats exposed
ovarian function in the adult rat. Reproduction 2011;141:241‑8. to endotoxin as neonates. J Neuroimmunol 2010;225:77‑81.
2. Korosi A, Naninck EF, Oomen CA, Schouten M, Krugers H, 19. Murray F, Smith DW, Hutson PH. Chronic low dose corticosterone
Fitzsimons C, Lucassen PJ. Early‑life stress mediated modulation of exposure decreased hippocampal cell proliferation, volume and
adult neurogenesis and behavior. Behav Brain Res 2012;227:400‑9. induced anxiety and depression like behaviours in mice. Eur J
3. Spencer SJ, Galic MA, Pittman QJ. Neonatal programming of innate Pharmacol 2008;583:115‑27.
immune function. Am J Physiol Endocrinol Metab 2011;300:E11‑8.
4. Asiaei M, Solati J, Salari AA. Prenatal exposure to LPS leads to
long‑lasting physiological consequences in male offspring. Dev Cite this article as: Majidi-Zolbanin J, Doosti MH, Baradaran B, Amani M,
Psychobiol 2011;53:828‑38. Azarfarin M, Salari AA. Neonatal immune activation during early and late
5. Babri S, Doosti MH, Salari AA. Strain‑dependent effects of prenatal postnatal brain development differently influences depression-related behaviors
in adolescent and adult C57BL/6 mice. Neuroimmunol Neuroinflammation
maternal immune activation on anxiety‑ and depression‑like 2014;1(1):35-9.
behaviors in offspring. Brain Behav Immun 2014;37:164‑76.
6. Doosti MH, Bakhtiari A, Zare P, Amani M, Majidi‑Zolbanin N, Babri S, Source of Support: Nil. Conflict of Interest: No.
Salari AA. Impacts of early intervention with fluoxetine following Received: 28-04-2014; Accepted: 30-05-2014

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