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reduced blood flow in the contralateral hemisphere. Furie KL, Howard VJ, Lichtman JH, Lisabeth LD, Piña IL,
This is an interesting observation as it suggests that even Reeves MJ, Rexrode KM, Saposnik G, Singh V, Towfighi A,
a focal ischemic stroke induces changes throughout Vaccarino V, Walters MR; American Heart Association Stroke
Council, Council on Cardiovascular and Stroke Nursing, Council
the brain. on Clinical Cardiology, Council. Guidelines for the prevention of
stroke in women: a statement for healthcare professionals from the
To further assess, the underlying mechanisms of smaller American Heart Association/American Stroke Association. Stroke
infarcts seen in aged mice, we investigated differences in 4. 2014;45:1545‑88.
Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N,
blood-brain barrier breakdown after stroke. Somewhat Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd‑Jones D,
surprisingly, IgG extravasation at both 24 h and 72 h McDermott M, Meigs J, Moy C, Nichol G, O’Donnell C, Roger V,
after stroke was lower in aged mice compared with Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y; American Heart
young mice, which likely correlated with the existence Association Statistics Committee and Stroke Statistics. Heart disease
and stroke statistics – 2008 update: a report from the American Heart
of smaller infarcts. Association Statistics Committee and Stroke Statistics Subcommittee.
Circulation 2008;117:e25‑146.
Despite some limitations, this is a very interesting 5. Agarwal S, Scoffings DJ, Jones PS, Marrapu ST, Barry PJ,
study as it is the first to utilize LSF to investigate O’Brien EW, Baron JC, Warburton EA. Interaction of age with the
blood flow changes in aged animals. The mechanism ischaemic penumbra, leptomeningeal collateral circulation and
haemodynamic variables in acute stroke: a pilot study. J Neurol
responsible for the higher mortality and poorer recovery Neurosurg Psychiatry 2013;84:271‑6.
seen in aged and elderly animals remain a mystery. 6. Liu F, Benashski SE, Persky R, Xu Y, Li J, McCullough LD. Age‑related
Age-related changes in neuroinflammation and the changes in AMP‑activated protein kinase after stroke. Age (Dordr)
immune response to stroke are areas under intense 7. 2012;34:157‑68.
Venna VR, Xu Y, Doran SJ, Patrizz A, McCullough LD. Social
investigation by a number of researchers and will interaction plays a critical role in neurogenesis and recovery after
hopefully be answered in the future. stroke. Transl Psychiatry 2014;4:e351.
8. Machado MC, Coelho AM, Carneiro D’Albuquerque LA, Jancar S.
REFERENCES Effect of ageing on systemic inflammatory response in acute
pancreatitis. Int J Inflam 2012;2012:270319.
9. Petcu EB, Smith RA, Miroiu RI, Opris MM. Angiogenesis in old‑aged
1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, subjects after ischemic stroke: a cautionary note for investigators.
Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, J Angiogenes Res 2010;2:26.
Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM,
Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH,
Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Cite this article as: Venna VR, McCullough LD. Differences in stroke damage
Mohler ER. Heart disease and stroke statistics – 2014 update: a report in aged mice may not be due to differential cerebral blood flow dynamics.
Neuroimmunol Neuroinflammation 2014;1(1):13-4.
from the American Heart Association. Circulation 2014;129:e28‑292.
2. Venna VR, McCullough LD. Role of social factors on cell death, Source of Support: This work was supported by the grants from American
cerebral plasticity and recovery after stroke. Metab Brain Dis 2014; Heart Association and the National Institutes of Health/National Institute of
Neurological Disorders and Stroke. Conflict of Interest: No.
22:301‑22.
3. Bushnell C, McCullough LD, Awad IA, Chireau MV, Fedder WN, Received: 01-05-2014; Accepted: 30-05-2014

14 Neuroimmunol Neuroinflammation | Volume 1 | Issue 1 | June 2014