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Li et al. Metab Target Organ Damage. 2025;5:19 https://dx.doi.org/10.20517/mtod.2025.05 Page 7 of 8

CONCLUSION
In conclusion, the discovery of the OCM-Hcy-MASLD axis and its sex-specific characteristics has opened
new avenues for improving perioperative management and long-term prognosis. Looking ahead, the
integration of multi-omics data - including metabolomics, epigenomics, and microbiomics - coupled with
the establishment of an OCM-Hcy axis-centered biomarker monitoring system and the combination of
precision surgery with individualized metabolic interventions, holds promise for fundamentally enhancing
outcomes in patients with MASLD-related PLC. This paradigm shift not only represents an evolution from
mere surgical resection to comprehensive metabolic regulation but also marks a significant step forward in
hepatobiliary surgery toward the era of precision medicine.

DECLARATIONS
Authors’ contributions
Conceptualized the commentary, conducted the literature review, and contributed to the writing and
editing of the manuscript: Li ZL, Tang ZH
Assisted in the literature: Chen JL, Tang Y, Qin DL

Availability of data and materials
Not applicable.

Financial support and sponsorship
None.

Conflicts of interest
Tang ZH is a Junior Editorial Board member of the journal Metabolism and Target Organ Damage. Tang
ZH was not involved in any steps of editorial processing, notably including reviewers’ selection, manuscript
handling and decision making. The other authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2025.

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