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Shimada et al. Mini-invasive Surg 2019;3:7 I http://dx.doi.org/10.20517/2574-1225.2018.78 Page 3 of 11

Xu et al. [13] (2018) China Retrospective Cohort 430 cT2-4a N0-3b LDG 39.8% LTG 60.2% 283.8 273.7 Excluded IB 10.7% IIA 16.0% IIB 20.9% IIIA 18.1% IIIB 22.8% IIIC 11.4% Grade II 2.8% ≥ Grade III 2.6% 0.2% 5-year OS 51.2% DFS 52.8%

Kinoshita et al. [12] (2018) Japan Multicenter Cohort PSM 305 c-Stage II/III LDG 51.5% LTG 42.0% LPG 0.7% UR 2.0% Bypass 3.9% 365 140 4 (1.3%) IA 4.3% IB 5.9% IIA 15.7% IIB 15.4% IIIA 15.4% IIIB 19.7% IIIC 15.4% IV 8.2% ≥ Grade 2 20.1% 0.3% 5-year OS 53.0% RFS 72%

Park et al. [11] (2018) Korea Phase II 100 cT2-4a N0-3 LDG 94% LTG 4% 257.4 - 2 (2%) IA 27% IB 15.0% IIA 18.0% IIB 11.0% IIIA 8.0% IIIB 15.0% IIIC 5.0% IV 1.0% 17% 0% 3-year DFS 80.1%

Li et al. [10] (2018) China PSM 410 pT2-4a N0-3b LDG 38.6% LTG 61.4% - - - IB 12.2% IIA 21.5% IIB 19.3% IIIA 22.0% IIIB 20% IIIC 5.1% - - 5-year OS 52.0% DFS 46.8%

Lee et al. [9] (2018) Korea Retrospective 160 cT2-4 LTG 10% LSTG 90% 174 99.5 Excluded IA 13.8% IB 11.9% IIA 27.5% IIB 20.6% IIIA 11.9% IIIB 15.0% IIIC 8.8% 14.3% 0% 3-year OS 80.5& DFS 73.7%
Table 1. The latest studies evaluating safety or survival rate about laparoscopic gastrectomy for advanced gastric cancer

Lin et al. [8] (2016) China PSM 539 pT2-4a N0-3b LTG 63.1% LDG 36.9% - - - IB 9.5% IIA 8.2% IIB 13.9% IIIA 12.4% IIIB 20.4% IIIC 35.6% - - 5-year OS 58.8%

Hao et al. [7] (2016) China Retrospective 579 cT2-3 LPG 9.7% LDG 63.8% LTG 25.8% 257.8 154.5 35 (5.57%) IB 14.8% IIA 22.6% IIB 26.3% IIIA 36.3% 6.4% - 5-year OS 57.65% RR 31.2% PSM: propensity score method; c: clinical; p: pathological; LDG: laparoscopic distal gastrectomy; LPG: laparoscopic proximal gastrectomy; LTG: laparoscopic total gastrectomy; LSTG: laparoscopic subtotal gastrectomy; UR: unresected; p-Stage: pathological stage

Li et al. [6] (2016) China PSM 101 - LDG 37.6% LTG 62.4% 297.4 131.9 - II 57.4% IIIA 23.8% IIIB 18.8% 21.8% 1% -

Okabe et al. [5] (2016) Japan Phase II 73 cT2-4b N0-3 LDG 56% LTG 43% UR 1% 366 60 0 CR 1% IA 3% IIA 1% IIB 7% IIIA 11% IIIB 7% IIIC 8% IV 4% ≥ Grade II 20.5% 1.4% -

Lee et al. [4] (2016) Korea Phase III 526 cT2-4a N0-2 LDG 100% - 231.2 - Awaiting the results 16.4% 0.38% Ongoing in phaseIII study

Hu et al. [3] (2016) China Phase II 528 cT2-4a N0-3 LDG 97.9% LTG 2.1% 217.3 105.5 6.4% IA 16.8% IB 12.3% IIA 12.7% IIB 13.7% IIIA 13.3% IIIB 14.1% IIIC 14.8% IV 2.1% 15.2% 0.4% Ongoing in phaseIII study

Inaki et al. [2] (2015) Japan Phase II 86 cT2-4 N0-2 LDG 100% 296 30 1 (1.2%) IA 26.7% IB 20.9% II 20.9% III 31.5% 15% 0% Ongoing in phaseIII study

Authors Country Analysis Sample size of LG cases Eligibility Surgery Operative time (min) Blood loss (mL) Conversion p-Stage Morbidity Mortality Lomg-term outcome gastrectomy