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Zhao et al. Mini-invasive Surg 2018;2:26  I  http://dx.doi.org/10.20517/2574-1225.2018.27                                          Page 9 of 10


               studies should evaluate the effect of tumour type, and the use of other treatments such as chemotherapy,
               on response to repeat ablation.


               In conclusion, despite these limitations, our study demonstrates that repeat MWA or RFA in locally pro-
               gressing tumours after initial ablation attempt(s) may be generally safe, well tolerated, and often achieves
               local control. These findings should be validated in larger prospective studies.


               DECLARATIONS
               Acknowledgments
               The authors would like to thank the Department of Nuclear Medicine at the Royal Brisbane and Women’s
               Hospital for their assistance with FDG-PET imaging.


               Authors’ contributions
               Design, literature research, data acquisition, drafted manuscript: Zhao H, Steinke K
               Data analysis: Zhao H, Okano S, Pelecanos A, Steinke K
               Substantively revised manuscript: Zhao H, Okano S, Pelecanos A, Steinke K

               Availability of data and materials
               Patients were identified using the radiology thermal ablation database at the Royal Brisbane and Women’s
               Hospital. Data were collected retrospectively through systematic review of patient charts and imaging. The
               de-identified data is available by contacting the corresponding author Associate Professor Karin Steinke.

               Financial support and sponsorship
               None.

               Conflicts of interest
               All authors declared that there are no conflicts of interest.


               Ethical approval and consent to participate
               Ethics approval for this study was obtained from the Royal Brisbane and Women’s Hospital Human Re-
               search Ethics Committee (HREC/14/QRBW/553).

               Consent for publication
               All patients provided written, informed consent.

               Copyright
               © The Author(s) 2018.


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