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Cangemi et al. Mini-invasive Surg 2022;6:3 Mini-invasive Surgery
DOI: 10.20517/2574-1225.2021.99

Review Open Access

Management of concomitant coronary artery disease

and aortic valve stenosis in the era of transcatheter
aortic valve treatment

1,2
1,2
1,2
1
1
Stefano Cangemi , Cristina Aurigemma , Enrico Romagnoli , Francesco Bianchini , Piergiorgio Bruno ,
1
1,2
Marialisa Nesta , Francesco Burzotta , Carlo Trani 1,2
1
Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.
2
Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome 00168, Italy.
Correspondence to: Prof. Francesco Burzotta, Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A.
Gemelli IRCCS, L.go A. Gemelli 1, Rome 00168, Italy. E-mail: francesco.burzotta@unicatt.it
How to cite this article: Cangemi S, Aurigemma C, Romagnoli E, Bianchini F, Bruno P, Nesta M, Burzotta F, Trani C. Management
of concomitant coronary artery disease and aortic valve stenosis in the era of transcatheter aortic valve treatment. Mini-invasive
Surg 2022;6:3. https://dx.doi.org/10.20517/2574-1225.2021.99
Received: 24 Aug 2021 First Decision: 11 Oct 2021 Revised: 27 Oct 2021 Accepted: 30 Nov 2021 Published: 6 Jan 2022
Academic Editors: Andrea Scotti, Giulio Belli Copy Editor: Yue-Yue Zhang Production Editor: Yue-Yue Zhang

Abstract
Severe calcific aortic stenosis (AS) and coronary artery disease (CAD) have common risk factors and are
frequently encountered in the same patient in clinical practice. CAD has been reported in ≥ 50% of AS patients
undergoing both surgical treatment and transcatheter aortic valve implantation (TAVI). In the last two decades,
TAVI has been established as a less invasive alternative to surgery. Recently, more and more young and low
surgical risk patients undergo TAVI. Despite the high prevalence of CAD in patients treated with TAVI, the
management strategy of concomitant CAD in these patients remains an area of considerable uncertainty. This
review provides an updated overview of the current knowledge about this topic and offers points for reflection
about the best approach to use.

Keywords: Severe aortic stenosis, coronary artery disease, transcatheter aortic valve implantation

INTRODUCTION
Aortic valve stenosis (AS) is the most common valvular heart disease undergoing surgical treatment in
developed countries . Its prevalence increases exponentially with age, and up to 5% of people between 75
[1]

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0
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