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Page 462 Julka et al. J Transl Genet Genom 2020;4:455-63 I http://dx.doi.org/10.20517/jtgg.2020.46

In conclusion, ACC is a relatively rare but distinctive tumor in the prostate gland. Infiltrating basaloid cells
forming dilated acinar and cribriform spaces with luminal basement like material are characteristic for this
tumor. Aggressive findings such as perineural invasion and extraprostatic extension may be found. IHC
evaluation shows that the tumor cells are at least focally positive for high-molecular-weight cytokeratin and
cytokeratin. Staining for PSA is usually negative, but positivity has been reported. The main differential
diagnosis includes benign basal cell hyperplasia and conventional adenocarcinoma with cribriform
spaces. Although these tumors have a biological potential that allows metastasis in a few cases, current
treatment consists primarily of surgical resection along with close, long-term follow-up. In our case study,
we conclude that a novel phenotypic multi-dimensional assay (CANscript) holds the promise to solve the
diagnostic dilemma for rare cancers such as ACC of the prostate. Various drug combinations can be tested
on the CANscript platform along with an accurate prediction of the treatment response, thereby offering a
personalized way of treatment for an individual patient.

DECLARATIONS
Authors’ contributions
Study concept and design, analysis and interpretation of data, literature search and drafting of the
manuscript: Julka PK, Verma A
Critical revision of the manuscript for important intellectual content: Gupta S, Gupta K, Rathod R
Study supervision: Julka PK

Availability of data and materials
Clinical data and reports supporting the results reported in this article can be found in the patient’s medical
records.

Financial support and sponsorship
None.

Conflicts of interest
All authors declared that there are no conflicts of interest. No benefits in any form have been received or
will be received from a commercial party related directly or indirectly to the subject of this article.

Ethical approval and consent to participate
Ethical approval for the study was not applicable. Subject has given his written informed consent to publish
this case (including publication of images).

Consent for publication
Subject has given his written informed consent to publish this case (including publication of images).

Copyright
© The Author(s) 2020.

REFERENCES
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and
mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424.
2. Ferlay J, Ervik M, Lam F, et al. Global cancer observatory: cancer today. Lyon, France: International Agency for Research on Cancer;
2020. Available from: https://gco.iarc.fr/today/home. [Last accessed on 6 Nov 2020]
3. Moch H, Humphrey PA, Ulbright TM, Reuter VE. WHO Classification of Tumours of the Urinary System and Male Genital Organs. 4.
Lyon: IARC Press; 2016. Available from: https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours/WHO-
Classification-Of-Tumours-Of-The-Urinary-System-And-Male-Genital-Organs-2016. [Last accessed on 6 Nov 2020]
4. Humphrey PA. Unusual prostatic neoplasms. Prostate pathology. ASCP, Chicago; 2003a. Available from: http://ascpcdn.s3.amazonaws.