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Donskov et al. J Transl Genet Genom 2021;5:136-62 https://dx.doi.org/10.20517/jtgg.2021.12 Page 27

158. Nguyen A, Rauch TA, Pfeifer GP, Hu VW. Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions
to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. FASEB J
2010;24:3036-51. DOI PubMed PMC
159. Jetten AM. Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular
metabolism. Nucl Recept Signal 2009;7:e003. DOI PubMed PMC
160. Grayaa S, Zerbinati C, Messedi M, et al. Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker
for Autism Spectrum Disorders. Biochimie 2018;153:80-5. DOI PubMed
161. de Vera IM, Giri PK, Munoz-Tello P, et al. Identification of a binding site for unsaturated fatty acids in the orphan nuclear receptor
nurr1. ACS Chem Biol 2016;11:1795-9. DOI PubMed PMC
162. Willems S, Kilu W, Ni X, et al. The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs. Commun
Chem 2020;3:85. DOI
163. Pan T, Zhu W, Zhao H, et al. Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo.
Brain Res 2008;1222:222-9. DOI PubMed
164. Decressac M, Volakakis N, Björklund A, Perlmann T. NURR1 in Parkinson disease--from pathogenesis to therapeutic potential. Nat
Rev Neurol 2013;9:629-36. DOI PubMed
165. Zhou J, Oakley RH, Cidlowski JA. DAX-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X-
chromosome, gene 1) selectively inhibits transactivation but not transrepression mediated by the glucocorticoid receptor in a LXXLL-
dependent manner. Mol Endocrinol 2008;22:1521-34. DOI PubMed PMC
166. Obradović D, Tirard M, Némethy Z, Hirsch O, Gronemeyer H, Almeida OF. DAXX, FLASH, and FAF-1 modulate mineralocorticoid
and glucocorticoid receptor-mediated transcription in hippocampal cells--toward a basis for the opposite actions elicited by two
nuclear receptors? Mol Pharmacol 2004;65:761-9. DOI PubMed
167. Zhao L, Zhou S, Gustafsson JÅ. Nuclear receptors: recent drug discovery for cancer therapies. Endocr Rev 2019;40:1207-49. DOI
PubMed
168. Santos R, Ursu O, Gaulton A, et al. A comprehensive map of molecular drug targets. Nat Rev Drug Discov 2017;16:19-34. DOI
PubMed PMC
169. Marciano DP, Chang MR, Corzo CA, et al. The therapeutic potential of nuclear receptor modulators for treatment of metabolic
disorders: PPARγ, RORs, and Rev-erbs. Cell Metab 2014;19:193-208. DOI PubMed
170. McKenna NJ. Research resources for nuclear receptor signaling pathways. Mol Pharmacol 2016;90:153-9. DOI PubMed PMC
171. Corona JC, Duchen MR. PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease. Free Radic Biol Med
2016;100:153-63. DOI PubMed PMC
172. Moutinho M, Codocedo JF, Puntambekar SS, Landreth GE. Nuclear receptors as therapeutic targets for neurodegenerative diseases:
lost in translation. Annu Rev Pharmacol Toxicol 2019;59:237-61. DOI PubMed PMC
173. Kim CH, Han BS, Moon J, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an
animal model of Parkinson's disease. Proc Natl Acad Sci U S A 2015;112:8756-61. DOI PubMed PMC
174. Tong M, Dominguez C, Didsbury J, de la Monte SM. Targeting Alzheimer's disease neuro-metabolic dysfunction with a small
molecule nuclear receptor agonist (T3D-959) reverses disease pathologies. J Alzheimers Dis Parkinsonism 2016;6:238. DOI
PubMed PMC
175. Sharma RP. Schizophrenia, epigenetics and ligand-activated nuclear receptors: a framework for chromatin therapeutics. Schizophr
Res 2005;72:79-90. DOI PubMed
176. Carta MG, Paribello P, Preti A. How promising is neuroactive steroid drug discovery? Expert Opin Drug Discov 2018;13:993-5.
DOI PubMed
177. Lerner V, Miodownik C, Gibel A, et al. The retinoid X receptor agonist bexarotene relieves positive symptoms of schizophrenia: a 6-
week, randomized, double-blind, placebo-controlled multicenter trial. J Clin Psychiatry 2013;74:1224-32. DOI PubMed
178. Touma KTB, Zoucha AM, Scarff JR. Liothyronine for depression: a review and guidance for safety monitoring. Innov Clin Neurosci
2017;14:24-9. PubMed PMC
179. Layton A. The use of isotretinoin in acne. Dermatoendocrinol 2009;1:162-9. DOI PubMed PMC
180. Song X, Chen J, Zhao M, et al. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor
coactivator-3. Proc Natl Acad Sci U S A 2016;113:4970-5. DOI PubMed PMC
181. Raj GV, Sareddy GR, Ma S, et al. Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor
positive human breast cancers. Elife 2017;6:e26857. DOI PubMed PMC
182. Wang L, Cheng CM, Qin J, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer
treatment. Sci Adv 2020;6:eaaz8031. DOI PubMed PMC