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J Cancer Metastasis Treat 2020;6:5 I http://dx.doi.org/10.20517/2394-4722.2020.13 Page 31 of 38

Results: We found that glucose is necessary for cell migration, with IL-6 promoting glucose uptake and cell
motility. On the contrary, inhibiting glucose uptake or its utilization blocks cancer cell migration while up-
regulating autophagy.

Conclusion: Our data indicate that the up-regulation of autophagy promoted by glucose deprivation
hampers ovarian cancer cell migration.

REFERENCES
1. Hollis RL, Gourley C. Genetic and molecular changes in ovarian cancer. Cancer Biol Med 2016;13:236-47.
2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin 2017;67:7-30.
3. Plante M, Rubin SC, Wong GY, Federici MG, Finstad CL, et al. Interleukin-6 level in serum and ascites as a prognostic factor in patients
with epithelial ovarian cancer. Cancer 1994;73:1882-8.
4. Soga T. Cancer metabolism: key players in metabolic reprogramming. Cancer Sci 2013;104:275-81.

43. Trousseau’s syndrome in association with lung adenocarcinoma

Abdulrahman Hakami

Jazan University, Jazan 45142, KSA.

Background: Trousseau’s syndrome (TS) is a hypercoagulability manifestation of paraneoplastic syndrome,
known as a variant of cancer-associated thrombosis and defined as a migratory thrombophlebitis found
typically in patients with an underlying malignancy. TS commonly occurs in pancreatic cancer (24%), lung
cancer (20%), prostate cancer (13%), and stomach cancer (12%), followed by breast and colon cancer.

Case presentation: Here, we describe the case of a 50-year-old male patient, who is a nonsmoker. During
a checkup for work, he was found to have a highly positive Mantoux test (TBT), thus a chest X-ray was
ordered. He had a previous chronic history of burning sensation in both feet, responding to analgesic drugs.
There was no history of shortness of breath,r cough, fever, night sweating, weight loss, loss of appetite,
or fatigue. Auscultation of chest X-ray revealed a mass in the left upper lobe of lung. The computed
tomography (CT) of chest showed a 5.5 cm × 4.3 cm left lingual superior segment lobulated mass with left
hilar and mediastinal lymph node enlargement. In addition, the CT reported bone metastasis in vertebra,
confirming the bone scan. Tumor markers were negative. CT guided biopsy for this lesion in the left upper
chest was performed and the histopathology result showed poorly differentiated adenocarcinoma. The
following molecular studies were negative: epidermal growth factor receptor (EGFR), anaplastic lymphoma
kinase, ROS, and PD-1. The patient was referred to the oncology center as a case of lung adenocarcinoma
with distant metastasis, stage T4bN2bM1, and started in cisplatin and Alimta chemotherapy. Spiral CT
revealed incidental finding of multiple filling defects, indicating segmental pulmonary embolism. Due to
leg pain, Doppler of lower limb was also performed, showing deep venous thrombosis in the left limb.
Enoxaparin was commenced at full dose. This case report indicated a TS cancer-associated thrombosis.
The patient, after receiving the first cycle of chemotherapy, was discharged on enoxaparin, was stable, and
returned to his job.

Conclusion: TS, a paraneoplastic manifestation, must be considered in patients with advanced stages of
cancer, regardless of the primary site of the cancer. In lung cancer, paraneoplastic syndrome presents more
frequently with small cell carcinoma (in 10% of patients), but, regarding TS in the literature, previous cases
reported adenocarcinoma was the most prevalent histology associated with thrombosis.