Page 482 - Read Online

Page 34 of 40 Maner et al. J Cancer Metastasis Treat 2020;6:37 I http://dx.doi.org/10.20517/2394-4722.2020.60

1998;391:90-2.
13. Marzuka AG, Book SE. Basal cell carcinoma: pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management.
Yale J Biol Med 2015;88:167-79.
14. Gutzmer R, Solomon JA. Hedgehog pathway inhibition for the treatment of basal cell carcinoma. Target Oncol 2019;14:253-67.
15. Pala R, Alomari N, Nauli SM. Primary cilium-dependent signaling mechanisms. Int J Mol Sci 2017;18:2272.
16. Hutchin ME, Kariapper MS, Grachtchouk M, Wang A, Wei L, et al. Sustained hedgehog signaling is required for basal cell carcinoma
proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev 2005;19:214-23.
17. Pontén F, Berg C, Ahmadian A, Ren ZP, Nistér M, et al. Molecular pathology in basal cell cancer with p53 as a genetic marker. Oncogene
1997;15:1059-67.
18. Sekulic A, Migden MR, Oro AE, Dirix L, Lewis KD, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J
Med 2012;366:2171-9.
19. Kong JH, Siebold C, Rohatgi R. Biochemical mechanisms of vertebrate hedgehog signaling. Development (Cambridge, England)
2019;146:dev166892.
20. Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature
2003;421:499-506.
21. Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, et al. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-
strand breaks. Nat Cell Biol 2006;8:37-45.
22. Shen T, Huang S. The role of Cdc25A in the regulation of cell proliferation and apoptosis. Anticancer Agents Med Chem 2012;12:631-9.
23. Decraene D, Agostinis P, Pupe A, de Haes P, Garmyn M. Acute response of human skin to solar radiation: regulation and function of the
p53 protein. J Photochem Photobiol B 2001;63:78-83.
24. Liu P, Gan W, Chin YR, Ogura K, Guo J, et al. PtdIns(3,4,5)P3-dependent activation of the mTORC2 kinase complex. Cancer Discov
2015;5:1194-209.
25. Zhang Y, Hunter T. Roles of Chk1 in cell biology and cancer therapy. Int J Cancer 2014;134:1013-23.
26. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, et al. p21 is a universal inhibitor of cyclin kinases. Nature 1993;366:701-4.
27. Rezvani HR, Mazurier F, Cario-André M, Pain C, Ged C, et al. Protective effects of catalase overexpression on UVB-induced apoptosis
in normal human keratinocytes. J Biol Chem 2006;281:17999-8007.
28. Sander CS, Hamm F, Elsner P, Thiele JJ. Oxidative stress in malignant melanoma and non-melanoma skin cancer. Br J Dermatol
2003;148:913-22.
29. Zhang J, Bowden GT. Activation of p38 MAP kinase and JNK pathways by UVA irradiation. Photochem Photobiol Sci 2012;11:54-61.
30. Nadeau PJ, Charette SJ, Toledano MB, Landry J. Disulfide bond-mediated multimerization of Ask1 and its reduction by thioredoxin-1
regulate H(2)O(2)-induced c-Jun NH(2)-terminal kinase activation and apoptosis. Mol Biol Cell 2007;18:3903-13.
31. Gross S, Knebel A, Tenev T, Neininger A, Gaestel M, et al. Inactivation of protein-tyrosine phosphatases as mechanism of UV-induced
signal transduction. J Biol Chem 1999;274:26378-86.
32. Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the
p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 2007;11:175-89.
33. Hess J, Angel P, Schorpp-Kistner M. AP-1 subunits: quarrel and harmony among siblings. J Cell Sci 2004;117:5965-73.
34. Silvers AL, Finch JS, Bowden GT. Inhibition of UVA-induced c-Jun N-terminal kinase activity results in caspase-dependent apoptosis in
human keratinocytes. Photochem Photobiol 2006;82:423-31.
35. Cooper SJ, MacGowan J, Ranger-Moore J, Young MR, Colburn NH, et al. Expression of dominant negative c-jun inhibits ultraviolet
B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model. Mol Cancer Res 2003;1:848-54.
36. Strozyk E, Kulms D. The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by
regulation of apoptosis, autophagy and senescence. Int J Mol Sci 2013;14:15260-85.
37. Coffer PJ, Burgering BM, Peppelenbosch MP, Bos JL, Kruijer W. UV activation of receptor tyrosine kinase activity. Oncogene
1995;11:561-9.
38. Arora A, Scholar EM. Role of tyrosine kinase inhibitors in cancer therapy. J Pharmacol Exp Ther 2005;315:971-9.
39. Spallone G, Botti E, Costanzo A. Targeted therapy in nonmelanoma skin cancers. Cancers (Basel) 2011;3:2255-73.
40. Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012;149:274-93.
41. Hafner C, Landthaler M, Vogt T. Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is not mediated by
oncogenic PIK3CA and AKT1 hotspot mutations. Exp Dermatol 2010;19:e222-7.
42. Ming M, He YY. PTEN: new insights into its regulation and function in skin cancer. J Invest Dermatol 2009;129:2109-12.
43. Hemmings BA, Restuccia DF. PI3K-PKB/Akt pathway. Cold Spring Harb Perspect Biol 2012;4:a011189.
44. Shimobayashi M, Hall MN. Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol
2014;15:155-62.
45. Gan X, Wang J, Su B, Wu D. Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. J
Biol Chem 2011;286:10998-1002.
46. Tu Y, Ji C, Yang B, Yang Z, Gu H, et al. DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates
ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival. Mol Cancer 2013;12:172.
47. Greer EL, Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005;24:7410-25.
48. Daitoku H, Fukamizu A. FOXO transcription factors in the regulatory networks of longevity. J Biochem 2007;141:769-74.
49. Bivik C, Ollinger K. JNK mediates UVB-induced apoptosis upstream lysosomal membrane permeabilization and Bcl-2 family proteins.