Page 793 - Read Online

Page 8 of 9 Zhang et al. J Cancer Metastasis Treat 2019;5:56 I http://dx.doi.org/10.20517/2394-4722.2018.112

lines showed a significantly increased binding of the SA-MIPs after treatment with recombinant cytokines
and with the cytokine cocktail from PHA-stimulated Jurkat cells. Here we demonstrate that SA-MIPs can be
an important tool in the investigation of overexpressed glycans in the tumor microenvironment.

DECLARATIONS
Authors’ contributions
Made substantial contributions to conception and design of the study and performed data analysis and
interpretation: Zhang Y, Llapashtica K, Wingren AG
Performed data acquisition, as well as provided administrative, technical, and material support: El-Schich Z
Provided administrative, technical, and material support: Shinde S, Sellergren B

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by the European Union’s Horizon 2020 research and innovation program under
the Marie Sklodowska-Curie grant agreement (No 721297); the Knowledge foundation, Biofilms Research
Center for Biointerfaces and Malmö University for financial support.

Conflicts of interest
All authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
The Author(s) 2019.

REFERENCE
1. Roshani R, McCarthy F, Hagemann T. Inflammatory cytokines in human pancreatic cancer. Cancer Lett 2014;345:157-63.
2. Soucek L, Lawlor E, Soto D, Shchors K, Swigart LB, et al. Mast cells are required for angiogenesis and macroscopic expansion of Myc-
induced pancreatic islet tumors. Nat Med 2007;13:1211-18.
3. Sparmann A, Bar-Sagi D. Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis. Cancer Cell
2004;5:447-58.
4. Padro M, Mejias-Luque R, Cobler L, Garrido M, Perez-Garay M, et al. Regulation of glycosltransferases and Lewis antigens expression
by IL-1B and IL-6 in human gastric cells. Glycoconj J 2011;28:99-110.
5. Mejias-Luque R, Linde, SK, Garrido M, Tye H, Najdovska M, et al. Inflammation modulates the expression of the intestinal mucins
MUC2 and MUC4 in gastric tumors. Oncogene 2010;12:1753-62.
6. Mejias-Luque R, Peiro S, Vincent A, Van Seuningen I, deBolos C. IL-6 induces MUC4 expression through gp130/STAT3pathway in
gastric cancer cell lines. Biochim. Biophys. Acta 2008;1783:1728-36.
7. Fuster MM, Esko JD. The sweet and sour of cancer: Glycans as novel therapeutic targets. Nat Rev Cancer 2005;5:526-42.
8. Varki, A. Sialic acids in human health and disease. (Invited Essay) Trends Mol. Med. 2008;14:351-60.
9. Dall'Olio, FC. Sialyltransferases in cancer. Glycoconjugate J 2001;18:841-50.
10. Czyzewska J, Guzińska-Ustymowicz K, Kemona A, Bandurski R. The expression of matrix metalloproteinase 9 and cathepsin B in
gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival. Folia Histochem Cytobiol 2008;46:57-
64.
11. Lin S, Kemmner W, Grigull Sand Schlag PM. Cell surface alpha 2,6 sialylation affects adhesion of breast carcinoma cells. Exp Cell Res
2002;276:101-10.