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Page 8 of 10 Grelet et al. J Cancer Metastasis Treat 2019;5:16 I http://dx.doi.org/10.20517/2394-4722.2018.85

However, because hnRNP-E1 is pleiotropic and ubiquitous, confining therapeutic strategies to tumor cells
may be challenging.

The phenotypic changes observed during cell plasticity and tumor progression demand radical proteomic
reprogramming of cells concomitant with a modulation of the codon usage by the translational machinery.
Accumulation of evidence advocates for acknowledgement of a primary role for hnRNP E1 in cell plasticity,
and this is reinforced by identification of mechanisms involving hnRNP E1 that directly or indirectly
converge upon the translational control of plasticity-associated proteins. We therefore propose that
hnRNP E1, together with its associated proteins, acts as a hub that orchestrates the demands of proteome
reprogramming during health and disease-associated cell plasticity.

DECLARATIONS
Acknowledgments
We would like to thank W. Scott Streitfeld for providing helpful feedback during the preparation of this
manuscript.

Authors’ contributions
Wrote the manuscript: Grelet S
Validated the manuscript: Howe PH

Availability of data and materials
Not applicable.

Financial support and sponsorship
This work was supported by Hollings Cancer Center Postdoctoral Fellowship to Grelet S and the National
Cancer Institute (CA154663) to Howe PH.

Conflicts of interest
Both authors declared that there are no conflicts of interest.

Ethical approval and consent to participate
Not applicable.

Consent for publication
Not applicable.

Copyright
© The Author(s) 2019.

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