Page 65 - Read Online
P. 65
Wang et al. Genotoxic NF-kB activation in cancer
65. Stilmann M, Hinz M, Arslan SC, Zimmer A, Schreiber V, Scheidereit 2011;471:633-6.
C. A nuclear poly(ADP-ribose)-dependent signalosome confers DNA 82. Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser
damage-induced IkappaB kinase activation. Mol Cell 2009;36:365-78. E, Feltham R, Vince J, Warnken U, Wenger T, Koschny R, Komander D,
66. Fu K, Sun X, Wier EM, Hodgson A, Liu Y, Sears CL, Wan F. Sam68/ Silke J, Walczak H. Recruitment of the linear ubiquitin chain assembly
KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic complex stabilizes the TNF-R1 signaling complex and is required for
stress-induced NF-kappaB activation. Elife 2016;5:e15018. TNF-mediated gene induction. Mol Cell 2009;36:831-44.
67. Sheng YH, He Y, Hasnain SZ, Wang R, Tong H, Clarke DT, Lourie 83. Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K,
R, Oancea I, Wong KY, Lumley JW, Florin TH, Sutton P, Hooper JD, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S,
McMillan NA, McGuckin MA. MUC13 protects colorectal cancer Takao T, Tanaka K, Iwai K. Involvement of linear polyubiquitylation
cells from death by activating the NF-kappaB pathway and is a of NEMO in NF-kappaB activation. Nat Cell Biol 2009;11:123-32.
potential therapeutic target. Oncogene 2017;36:700-13. 84. Lo YC, Lin SC, Rospigliosi CC, Conze DB, Wu CJ, Ashwell JD,
68. Wu ZH, Shi Y, Tibbetts RS, Miyamoto S. Molecular linkage between Eliezer D, Wu H. Structural basis for recognition of diubiquitins by
the kinase ATM and NF-kappaB signaling in response to genotoxic NEMO. Mol Cell 2009;33:602-15.
stimuli. Science 2006;311:1141-6. 85. Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R,
69. Jin HS, Lee DH, Kim DH, Chung JH, Lee SJ, Lee TH. cIAP1, cIAP2, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki
and XIAP act cooperatively via nonredundant pathways to regulate S, Dikic I. Specific recognition of linear ubiquitin chains by NEMO is
genotoxic stress-induced nuclear factor-kappaB activation. Cancer important for NF-kappaB activation. Cell 2009;136:1098-109.
Res 2009;69:1782-91. 86. Josson S, Xu Y, Fang F, Dhar SK, St Clair DK, St Clair WH. RelB
70. Hinz M, Stilmann M, Arslan SC, Khanna KK, Dittmar G, Scheidereit regulates manganese superoxide dismutase gene and resistance to
C. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA ionizing radiation of prostate cancer cells. Oncogene 2006;25:1554-9.
damage signaling to ubiquitin-mediated NF-kappaB activation. Mol 87. Xu Y, Fang F, St Clair DK, Sompol P, Josson S, St Clair WH. SN52,
Cell 2010;40:63-74. a novel nuclear factor-kappaB inhibitor, blocks nuclear import of
71. Schoch S, Gundelfinger E. Molecular organization of the presynaptic RelB:p52 dimer and sensitizes prostate cancer cells to ionizing
active zone. Cell Tissue Res 2006;326:379-91. radiation. Mol Cancer Ther 2008;7:2367-76.
72. Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, 88. Lessard L, Begin LR, Gleave ME, Mes-Masson AM, Saad F. Nuclear
Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi localisation of nuclear factor-kappaB transcription factors in prostate
H, Takai Y. Cast: a novel protein of the cytomatrix at the active zone cancer: an immunohistochemical study. Br J Cancer 2005;93:1019-23.
of synapses that forms a ternary complex with RIM1 and munc13-1. J 89. Renner F, Schmitz ML. Autoregulatory feedback loops terminating
Cell Biol 2002;158:577-90. the NF-kappaB response. Trends Biochem Sci 2009;34:128-35.
73. Wang Y, Liu X, Biederer T, Sudhof TC. A family of RIM-binding 90. Ruland J. Return to homeostasis: downregulation of NF-κB responses.
proteins regulated by alternative splicing: implications for the genesis Nat immunol 2011;12:709-14.
of synaptic active zones. Proc Natl Acad Sci U S A 2002;99:14464-9. 91. Chiao PJ, Miyamoto S, Verma IM. Autoregulation of I kappa B alpha
74. Ducut-Sigala JL, Bottero V, Young DB, Shevchenko A, Mercurio F, activity. Proc Natl Acad Sci U S A 1994;91:28-32.
Verma IM. Activation of transcription factor NF-kappaB requires ELKS, 92. Sun SC, Ganchi PA, Ballard DW, Greene WC. NF-kappa B controls
an IkappaB kinase regulatory subunit. Science 2004;304:1963-7. expression of inhibitor I kappa B alpha: evidence for an inducible
75. Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar autoregulatory pathway. Science 1993;259:1912-5.
V. ATM- and NEMO-dependent ELKS ubiquitination coordinates 93. Beg AA, Sha WC, Bronson RT, Baltimore D. Constitutive NF-kappa
TAK1-mediated IKK activation in response to genotoxic stress. Mol B activation, enhanced granulopoiesis, and neonatal lethality in I
Cell 2010;40:75-86. kappa B alpha-deficient mice. Genes Dev 1995;9:2736-46.
76. Niu J, Shi Y, Iwai K, Wu ZH. LUBAC regulates NF-kappaB activation 94. Brummelkamp TR, Nijman SM, Dirac AM, Bernards R. Loss of the
upon genotoxic stress by promoting linear ubiquitination of NEMO. cylindromatosis tumour suppressor inhibits apoptosis by activating
EMBO J 2011;30:3741-53. NF-kappaB. Nature 2003;424:797-801.
77. Komander D, Reyes-Turcu F, Licchesi JDF, Odenwaelder P, 95. Jono H, Lim JH, Chen LF, Xu H, Trompouki E, Pan ZK, Mosialos G,
Wilkinson KD, Barford D. Molecular discrimination of structurally Li JD. NF-kappaB is essential for induction of CYLD, the negative
equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep regulator of NF-kappaB: evidence for a novel inducible autoregulatory
2009;10:466-73. feedback pathway. J Biol Chem 2004;279:36171-4.
78. Kirisako T, Kamei K, Murata S, Kato M, Fukumoto H, Kanie M, 96. Wertz IE, O’Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu
Sano S, Tokunaga F, Tanaka K, Iwai K. A ubiquitin ligase complex P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM.
assembles linear polyubiquitin chains. Embo J 2006;25:4877-87. De-ubiquitination and ubiquitin ligase domains of A20 downregulate
79. Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, NF-kappaB signalling. Nature 2004;430:694-9.
Haas TL, Webb AI, Rickard JA, Anderton H, Wong WWL, Nachbur 97. Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, Ma A.
U, Gangoda L, Warnken U, Purcell AW, Silke J, Walczak H. Failure to regulate TNF-induced NF-kappaB and cell death responses
Linear ubiquitination prevents inflammation and regulates immune in A20-deficient mice. Science 2000;289:2350-4.
signalling. Nature 2011;471:591-6. 98. Cheng J, Kang X, Zhang S, Yeh ET. SUMO-specific protease 1
80. Ikeda F, Deribe YL, Skanland SS, Stieglitz B, Grabbe C, Franz- is essential for stabilization of HIF1alpha during hypoxia. Cell
Wachtel M, van Wijk SJL, Goswami P, Nagy V, Terzic J, Tokunaga 2007;131:584-95.
F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, 99. Hay RT. SUMO-specific proteases: a twist in the tail. Trends cell biol
Schaefer L, Rittinger K, Macek B, Dikic I. SHARPIN forms a linear 2007;17:370-6.
ubiquitin ligase complex regulating NF-κB activity and apoptosis. 100. Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S. NF-kappaB
Nature 2011;471:637-41. induction of the SUMO protease SENP2: a negative feedback loop
81. Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata to attenuate cell survival response to genotoxic stress. Mol Cell
S, Tanaka K, Nakano H, Iwai K. SHARPIN is a component of the 2011;43:180-91.
NF-kB-activating linear ubiquitin chain assembly complex. Nature 101. Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, Wei G,
Journal of Cancer Metastasis and Treatment ¦ Volume 3 ¦ March 27, 2017 57