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Du et al.                                                                                                                                                                                                                   TLRs in cancer

           Financial support and sponsorship                     receptor 3. Nature 2001;413:732-8.
           This work  was supported  in part by NIH Grant     17.  Poltorak  A,  He  X,  Smirnova  I,  Liu  MY,  Van  Huffel  C,  Du  X,
           CA176698 and the Texas A&M Health Science Center.     Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-
                                                                 Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/
                                                                 HeJ  and  C57BL/10ScCr  mice:  mutations  in  Tlr4  gene.  Science
           Conflicts of interest                                 1998;282:2085-8.
           There are no conflicts of interest.                18.  Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR,
                                                                 Eng  JK,  Akira  S,  Underhill  DM,  Aderem  A.  The  innate  immune
           Patient consent                                       response  to  bacterial  flagellin  is  mediated  by  Toll-like  receptor  5.
           There is no patient involved.                         Nature 2001;410:1099-103.
                                                              19.  Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S,
           Ethics approval                                       Lipford G, Wagner H, Bauer S. Species-specific recognition of single-
                                                                 stranded RNA via toll-like receptor 7 and 8. Science 2004;303:1526-9.
           This article does not contain any studies with human   20.  Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting
           participants or animals.                              of innate immunity with Toll-like receptor agonists and antagonists.
                                                                 Nat Med 2007;13:552-9.
           REFERENCES                                         21.  Zhang  D,  Zhang  G,  Hayden  MS,  Greenblatt  MB,  Bussey  C,
                                                                 Flavell RA, Ghosh S. A toll-like receptor that prevents infection by
           1.   Medzhitov  R,  Janeway  CA  Jr.  Innate  immunity:  the  virtues  of  a   uropathogenic bacteria. Science 2004;303:1522-6.
               nonclonal system of recognition. Cell 1997;91:295-8.  22.  O’Neill LA, Bowie AG. The family of five: TIR-domain-containing
           2.   Beutler B. Toll-like receptors: how they work and what they do. Curr   adaptors  in  Toll-like  receptor  signalling.  Nat  Rev  Immunol
               Opin Hematol 2002;9:2-10.                         2007;7:353-64.
           3.   Akira  S,  Uematsu  S, Takeuchi O.  Pathogen  recognition and  innate   23.  Curtin JF, Liu N, Candolfi M, Xiong W, Assi H, Yagiz K, Edwards
               immunity. Cell 2006;124:783-801.                  MR, Michelsen KS, Kroeger KM, Liu C, Muhammad AK, Clark MC,
           4.   Pandey S, Kawai T, Akira S. Microbial sensing by Toll-like receptors   Arditi M, Comin-Anduix B, Ribas A, Lowenstein PR, Castro MG.
               and intracellular nucleic acid sensors. Cold Spring Harb Perspect Biol   HMGB1  mediates  endogenous  TLR2  activation  and  brain  tumor
               2015;7:a016246.                                   regression. PLoS Med 2009;6:e10.
           5.   Schenten  D,  Nish  SA, Yu  S, Yan  X,  Lee  HK,  Brodsky  I,  Pasman   24.  Ribeiro RA, Wanderley CW, Wong DV, Mota JM, Leite CA, Souza
               L,  Yordy  B,  Wunderlich  FT,  Bruning  JC,  Zhao  H,  Medzhitov  R.   MH,  Cunha  FQ,  Lima-Junior  RC.  Irinotecan-  and  5-fluorouracil-
               Signaling through the adaptor molecule MyD88 in CD4+ T cells is   induced intestinal mucositis: insights into pathogenesis and therapeutic
               required  to  overcome  suppression  by  regulatory  T  cells.  Immunity   perspectives. Cancer Chemother Pharmacol 2016;78:881-93.
               2014;40:78-90.                                 25.  Kuo WT, Lee TC, Yu LC. Eritoran suppresses colon cancer by altering
           6.   Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM,   a functional balance in Toll-like receptors that bind lipopolysaccharide.
               Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan   Cancer Res 2016;76:4684-95.
               X,  Zhang  H,  Boger  DL,  Beutler  B.  TLR4/MD-2  activation  by  a   26.  Prakash  H,  Nadella  V,  Singh  S,  Schmitz-Winnenthal  H.  CD14/
               synthetic agonist with no similarity to LPS. Proc Natl Acad Sci U S A   TLR4 priming potentially recalibrates and exerts anti-tumor efficacy
               2016;113:E884-93.                                 in  tumor  associated  macrophages  in  a  mouse  model  of  pancreatic
           7.   Kassiotis G, Stoye JP. Immune responses to endogenous retroelements:   carcinoma. Sci Rep 2016;6:31490.
               taking the bad with the good. Nat Rev Immunol 2016;16:207-19.  27.  Llitjos JF, Auffray C, Alby-Laurent F, Rousseau C, Merdji H, Bonilla
           8.   Kawai T, Akira S. Pathogen recognition with Toll-like receptors. Curr   N, Toubiana J, Belaidouni N, Mira JP, Lucas B, Chiche JD, Pene F.
               Opin Immunol 2005;17:338-44.                      Sepsis-induced expansion of granulocytic myeloid-derived suppressor
           9.   Maglione  PJ,  Simchoni  N,  Cunningham-Rundles  C.  Toll-like   cells promotes tumour growth through Toll-like receptor 4. J Pathol
               receptor signaling in primary immune deficiencies. Ann N Y Acad Sci   2016;239:473-83.
               2015;1356:1-21.                                28.  Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy
           10.  O’Neill LA. Glycolytic reprogramming by TLRs in dendritic cells.   S, Hsu D, Xu R, Harpaz N, Dannenberg AJ, Subbaramaiah K, Cooper
               Nat Immunol 2014;15:314-5.                        HS,  Itzkowitz  SH,  Abreu  MT.  Toll-like  receptor-4  promotes  the
           11.  Santoni M, Andrikou K, Sotte V, Bittoni A, Lanese A, Pellei C, Piva   development of colitis-associated colorectal tumors. Gastroenterology
               F, Conti A, Nabissi M, Santoni G, Cascinu S. Toll like receptors and   2007;133:1869-81.
               pancreatic diseases: from a pathogenetic mechanism to a therapeutic   29.  Furrie E, Macfarlane S, Thomson G, Macfarlane GT; Microbiology
               target. Cancer Treat Rev 2015;41:569-76.          &  Gut  Biology  Group;  Tayside  Tissue  &  Tumour  Bank.  Toll-
           12.  Kawai T, Akira S. The role of pattern-recognition receptors in innate   like  receptors-2,  -3  and  -4  expression  patterns  on  human  colon
               immunity: update on Toll-like receptors. Nat Immunol 2010;11:373-84.  and  their  regulation  by  mucosal-associated  bacteria.  Immunology
           13.  Iwasaki A, Medzhitov R. Control of adaptive immunity by the innate   2005;115:565-74.
               immune system. Nat Immunol 2015;16:343-53.     30.  Zhou  M,  McFarland-Mancini  MM,  Funk  HM,  Husseinzadeh  N,
           14.  Shah  M,  Anwar  MA,  Kim  JH,  Choi  S.  Advances  in  antiviral   Mounajjed T, Drew AF. Toll-like receptor expression in normal ovary
               therapies targeting Toll-like receptors. Expert Opin Investig Drugs   and ovarian tumors. Cancer Immunol Immunother 2009;58:1375-85.
               2016;25:437-53.                                31.  Kelly MG, Alvero AB, Chen R, Silasi DA, Abrahams VM, Chan S,
           15.  Takeuchi  O,  Hoshino  K,  Kawai  T,  Sanjo  H,  Takada  H,  Ogawa  T,   Visintin  I,  Rutherford T,  Mor  G. TLR-4  signaling  promotes  tumor
               Takeda K, Akira S. Differential roles of TLR2 and TLR4 in recognition   growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res
               of gram-negative and gram-positive bacterial cell wall components.   2006;66:3859-68.
               Immunity 1999;11:443-51.                       32.  Niedzielska  I,  Niedzielski  Z,  Tkacz  M,  Orawczyk  T,  Ziaja  K,
           16.  Alexopoulou  L,  Holt  AC,  Medzhitov  R,  Flavell  RA.  Recognition   Starzewski J, Mazurek U, Markowski J. Toll-like receptors and the
               of double-stranded RNA and activation of NF-kappaB by Toll-like   tendency  of  normal  mucous  membrane  to  transform  to  polyp  or
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