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Adachi et al. J Cancer Metastasis Treat 2016;2:375-8 Journal of
DOI: 10.20517/2394-4722.2016.33
Cancer Metastasis and Treatment

www.jcmtjournal.com
Case Report Open Access

Pediatric gliomatosis cerebri presenting

with intratumoral hemorrhage leading to

poor outcome

Hiromasa Adachi, Masashi Kitagawa, Toshinari Kawasaki, Takafumi Wataya

Department of Neurosurgery, Shizuoka Children’s Hospital, Shizuoka 420-8660, Japan.
Correspondence to: Dr. Takafumi Wataya, Department of Neurosurgery, Shizuoka Children’s Hospital, 860 Urushiyama, Aoi-ku, Shizuoka 420-
8660, Japan. E-mail: watayatakafumi@gmail.com

How to cite this article: Adachi H, Kitagawa M, Kawasaki T, Wataya T. Pediatric gliomatosis cerebri presenting with intratumoral hemorrhage
leading to poor outcome. J Cancer Metastasis Treat 2016;2:375-8.

Dr. Takafumi Wataya is a chief neurosurgeon in Shizuoka Children’s Hospital, Japan, and a council member of
Japanese Society for Pediatric Neurosurgery. He had fellowships of skull base brain tumor surgery and pediatric
neurosurgery in North America. He got his PhD under professor Yoshiki Sasai, RIKEN institute, with inventing
methods to create hypothalamic neurons from pluripotent stem cells (SFEBq method).

ABSTRACT
Article history: Gliomatosis cerebri (GC) is an uncommon disease, defined as diffuse infiltration of
Received: 16-06-2016 neoplastic glial cells involving at least three cerebral lobes. GCs in young population
Accepted: 23-07-2016 are rare. We described a case of 14-year-old woman with GC who did not receive any
Published: 18-09-2016 recommended treatment, because the patient’s family refused. The patient had a rapid
deterioration in 5 months after first symptoms due to intratumoral bleeding. This is the
Key words: first case report of intratumoral bleeding after diagnosis of GC is made, resulting in poor
Gliomatosis cerebri, outcome. GC may acquire possibility of intratumoral hemorrhage through its development.
intratumoral hemorrhage,
pediatric

INTRODUCTION characterized by diffuse infiltration of glioma cells,
and defined with tumor invasion into more than three
Gliomatosis cerebri (GC) is an uncommon primary cerebral lobes. [1,2] It often infiltrates into bilateral
brain tumor that has quite malignant behavior. It is hemispheres, in some cases, even into the brainstem,

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