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Apart from local spread, the disease spreads to the pelvic and   imaging, associated lytic areas in calvarium on CECT with
           para-aortic lymph nodes and then by hematogenous route to   multiplicity can give a clue to metastatic nature of disease.
           the supra and infradiaphragmatic viscera.  About 5-35%   In our patient,  the disease was detected  at an advanced
                                             [2]
           eventually develops pulmonary metastases, [3,4]  3% develops   stage as the presenting symptom itself was metastases to
           liver metastases,  16% develops bone metastases. [4]  vertebrae  presenting  as neck  pain  she had  no symptoms
                        [5]
                                                              relating to carcinoma cervix until later.
           Skeletal  metastasis in carcinoma  cervix  occurs in  about
           0.8-23%  of cases. Bone metastases can be due to   Financial support and sponsorship
                  [1]
           local  extension, however, distant metastases  are due to   Nil.
           hematogenous dissemination.  These lesions are usually
           radiographically  lytic,  and patients  have recurrent  or   Conflicts of interest
           advanced  disease  with other  sites of metastases.  The   There are no conflicts of interest.
                                                     [6]
           metastatic sites are commonly the spine, followed by pelvic
           bones. Very few cases of metastases to the skull have been   REFERENCES
           identified, about five cases to the best of our knowledge.
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                       [7]
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           bone, other cases of skull metastases reported are Niloofar   2.   Kim RY, Weppelmann B, Salter MM, Brascho DJ. Skeletal metastasis
           Ahmadloo et al., , Mohanthy et al.,  Abhishek et al.,    from cancer of the uterine cervix: Frequency, patterns and radiotherapeutic
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                                                              3.   Barter JF, Soong SJ, Hatch KD, Orr JW, Shingleton HM. Diagnosis
           The case reported by Abhishek et al.  was similar to our   and treatment of pulmonary metastases from cervical  carcinoma.
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           case  where the  histlogical  subtype was adenosquamous   4.   Gynecol Oncol 1990;38:347-51.
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           thrombosis. Our patient  had transverse sinus thrombosis.   5.   Buchsbaum  HJ. Extrapelvic  lymph node metastases  in  cervical
           The  other  cases  were  of  squamous  cell  carcinoma.  Rath   carcinoma. Am J Obstet Gynecol 1979;133:814-24.
           et al.  and Agrawal et al.  reported cases with multiple   6.   Abdul-Karim FW, Kida M, Wentz WB, Carter JR, Sorensen K, Macfee
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                                                                 a clinicopathologic study. Gynecol Oncol 1990;39:108-14.
           In a recent analysis of 813 patients with stage IB disease,   7.   Yanuck MD, Kaufman RH, Woods KV, Adler-Storthz K. Cervical
           Look  et al.  noted a poorer survival for patients with   carcinoma metasatic to the skull, heart and lungs: analysis for human
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           extrapelvic  recurrences  than those with squamous or   8.   Ahmadloo N, Shapour O, Mansour A, Ahmad M, Mohammad M. Bony
                                                                 calvarium as the sole site of metastases in squamous cell carcinoma of
           adenocarcinoma  cell  types. Neuroendocrine  cervical   the uterine cervix. Middle East J Cancer 2010;1:185-8.
           tumors and glassy cell  tumors have  also been associated   9.   Mohanty A, Dutta D, Das S, Samanta D, Senapati S. Skull metastases
           with  hematogenous spread  with  early-stage  disease.  The   from carcinoma of cervix: a rare case and review of the literature. J
           aggressive disease in our patient could be explained by the   Obstet Gynaecol Res 2010;36:441-3.
           adenosquamous cell type of carcinoma she had.      10.  Abhishek A, Ouseph MM, Sharma P, Kamal V, Sharma M. Bulky
                                                                 scalp metastases and superior sagittal sinus thrombosis from a
           No reports have been published till date demonstrating fat   cervical  adenocarcinoma:  an  unusual  case.  J  Med Imaging Radiat
           containing metastases to skull as seen in our case. The spine   Oncol 2008;52:91-4.
           and pelvic metastases were not fat attenuating.    11.  Zilberlicht A, Voldavskv E, Lavie O, Auslender R, Shai A. Prolonged
                                                                 survival in a patient with isolated skull recurrence of cervical carcinoma -
           In a patient with carcinoma of cervix, metastases must be   Case report and review of the literature. Gynecol Oncol Rep 2014;11:20-2.
           included in the differentials of scalp lesions. The lesions   12.  Rath GK, Misra BK, Jayalakshmi S. Scalp metastasis of a uterine
                                                                 cervix carcinoma. Obstet Gynaecol Today 2000;8:488-9.
           may mimic sebaceous cysts and lipomas (in our case,   13.  Look KY, Brunetto  VL, Clarke-Pearson  DL,  Averette HE,  Major
           they  were  soft on clinical  exam  and  fat  containing  on   FJ, Alvarez RD, Homesley HD, Zaino RJ. An analysis of cell type
           computed tomography mimicking lipoma).  A history of   in patients with surgically staged IB carcinoma of the cervix:  A
           recent onset of swelling (present in our case) should prompt   Gynecologic Oncology Group study. Gynecol Oncol 1996;63:304-11.













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