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FUTURE DIRECTIONS                                 13.  Frucht H, Gazdar AF, Park JA, Oie H, Jensen RT. Characterization
                                                                  of functional  receptors for gastrointestinal  hormones on human
                                                                  colon cancer cells. Cancer Res 1992;52:1114-22.
            It is clear that muscarinic receptors and ligands play key   14.  Frucht H, Jensen RT, Dexter D, Yang WL, Xiao Y. Human colon
            roles in CRC progression. Unfortunately, there are no   cancer cell proliferation mediated by the M3 muscarinic cholinergic
            published translational  and clinical studies at this time.   receptor. Clin Cancer Res 1999;5:2532-9.
            Future studies focused on determining overexpression of   15.  Yang  WL,  Frucht  H.  Cholinergic  receptor  up-regulates  COX-2
            muscarinic receptors in different patient cohorts, relation   expression and prostaglandin E(2) production in colon cancer cells.
            to CRC staging, tumor differentiation and prognosis will   Carcinogenesis 2000;21:1789-93.
            shed more lights in the importance of muscarinic receptor   16.  Grando SA. Biological  functions of keratinocyte  cholinergic
            signaling in CRC.                                     receptors. J Investig Dermatol Symp Proc 1997;2:41-8.
                                                              17.  Schlereth  T, Birklein  F, an Haack  K, Schiffmann  S, Kilbinger
                                                                  H, Kirkpatrick  CJ,  Wessler I.  In vivo release of non-neuronal
            Another important  aspect  of MR signaling  in CRC is   acetylcholine  from the human skin as measured by dermal
            therapeutic potential of MR-based therapy. Because M1R   microdialysis:  effect of botulinum toxin.  Br J Pharmacol
            and M3R are both expressed abundantly in the intestinal   2006;147:183-7.
            epithelium, buy have distinct functions,  it is critical to   18.  Song P, Sekhon HS, Jia Y, Keller JA, Blusztajn JK, Mark GP, Spindel
                                             [45]
            develop M1R- and M3R-specifc ligands, and test their   ER. Acetylcholine is synthesized by and acts as an autocrine growth
                                                                  factor for small cell lung carcinoma. Cancer Res 2003;63:214-21.
            pharmacological  and  therapeutic  characteristics  both   19.  Tsuji S, Anglade P. Acetylcholine in neurons and paraneurons: a
            in vitro and  in vivo.  These studies will lay important   histochemical study. Arch Histol Cytol 1989;52:75-83.
            foundations for future human clinical trials that are focused   20.  Keely SJ. Epithelial acetylcholine -- a new paradigm for cholinergic
            on  MR-based  therapy.  In  addition,  colon-specific  drug   regulation  of  intestinal  fluid  and  electrolyte  transport.  J Physiol
            delivery systems  should be utilized to reduce unwanted   2011;589:771-2.
                          [49]
            systemic side-effects.                            21.  Rosas-Ballina M, Olofsson PS, Ochani M, Valdés-Ferrer SI, Levine
                                                                  YA, Reardon  C, Tusche  MW, Pavlov VA, Andersson U, Chavan
            Financial support and sponsorship                     S, Mak TW, Tracey  KJ. Acetylcholine-synthesizing T  cells  relay
                                                                  neural signals in a vagus nerve circuit. Science 2011;334:98-101.
            This work was supported by Merit Review Awards from   22.  Brandon  EP,  Lin  W,  D’Amour  KA,  Pizzo  DP,  Dominguez  B,
            the United States Department of Veterans Affairs Program   Sugiura Y, Thode S, Ko CP, Thal LJ, Gage FH, Lee KF. Aberrant
            (G. Xie and J. P. Raufman) and NIH R21-DK093406 and   patterning of neuromuscular synapses in choline acetyltransferase-
            T32 DK067872 (J. P. Raufman).                         deficient mice. J Neurosci 2003;23:539-49.
                                                              23. Klapproth H, Reinheimer  T, Metzen J, Münch M, Bittinger F,
            Conflicts of interest                                 Kirkpatrick CJ, Höhle KD,  Schemann M, Racké K,  Wessler I.
            There are no conflicts of interest.                   Non-neuronal acetylcholine,  a signalling molecule  synthezised
                                                                  by surface cells of rat and man.  Naunyn  Schmiedebergs Arch
                                                                  Pharmacol 1997;355:515-23.
            REFERENCES                                        24.  Cheng K, Samimi R, Xie G, Shant J, Drachenberg C, Wade M, Davis
                                                                  RJ, Nomikos G, Raufman JP. Acetylcholine release by human colon
            1.   Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A.   cancer cells mediates autocrine stimulation of cell proliferation. Am
                Global cancer statistics, 2012. CA Cancer J Clin 2015;65:87-108.  J Physiol Gastrointest Liver Physiol 2008;295:G591-7.
            2.   Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014.   25.  von Rosenvinge EC, Cheng K, Drachenberg CB, Fowler CB, Evers
                CA Cancer J Clin 2014;64:104-17.                  DL,  Xie  G,  Raufman  JP.  Bedside  to  bench:  role  of  muscarinic
            3.   Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer   receptor activation  in ultrarapid growth of colorectal cancer in a
                J Clin 2015;65:5-29.                              patient with pheochromocytoma. Mayo Clin Proc 2013;88:1340-6.
            4.   Modjtahedi  H, Essapen  S. Epidermal  growth  factor  receptor   26.  Raufman  JP,  Zimniak  P,  Bartoszko-Malik  A.  Lithocholyltaurine
                inhibitors  in cancer  treatment:  advances,  challenges  and   interacts with cholinergic receptors on dispersed chief cells from
                opportunities. Anticancer Drugs 2009;20:851-5.    guinea pig stomach. Am J Physiol 1998;274:G997-1004.
            5.   Overman  MJ, Hoff PM. EGFR-targeted  therapies  in  colorectal   27.  Raufman JP, Chen Y, Cheng K, Compadre C, Compadre L, Zimniak
                cancer. Dis Colon Rectum 2007;50:1259-70.         P. Selective interaction of bile acids with muscarinic receptors: a
            6.   Ilyas M.  Wnt signalling and the mechanistic  basis of tumour   case of molecular mimicry. Eur J Pharmacol 2002;457:77-84.
                development. J Pathol 2005;205:130-44.        28.  Cheng K, Khurana S, Chen Y, Kennedy RH, Zimniak P, Raufman JP.
            7.   Wess J. Molecular biology of muscarinic acetylcholine receptors.   Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic
                Crit Rev Neurobiol 1996;10:69-99.                 receptor antagonist. J Pharmacol Exp Ther 2002;303:29-35.
            8.   Wess J. Muscarinic acetylcholine  receptor knockout mice:  novel   29.  Cheng  K,  Chen  Y,  Zimniak  P,  Raufman  JP,  Xiao  Y,  Frucht  H.
                phenotypes and clinical implications. Annu Rev Pharmacol Toxicol   Functional  interaction  of lithocholic  acid  conjugates  with M3
                2004;44:423-50.                                   muscarinic receptors on a human colon cancer cell line. Biochim
            9.   Shah N, Khurana S, Cheng K, Raufman JP. Muscarinic receptors and   Biophys Acta 2002;1588:48-55.
                ligands in cancer. Am J Physiol Cell Physiol 2009;296:C221-32.  30.  Cheng K, Raufman JP. Bile acid-induced proliferation of a human
            10.  Spindel ER. Muscarinic receptor agonists and antagonists: effects   colon cancer cell line is mediated by transactivation of epidermal
                on cancer. Handb Exp Pharmacol 2012;208:451-68.   growth factor receptors. Biochem Pharmacol 2005;70:1035-47.
            11.  Spindel ER. Cholinergic targets in lung cancer. Curr Pharm Des   31.  Cheng K, Zimniak P, Raufman JP. Transactivation of the epidermal
                2016;22:2152-9.                                   growth factor  receptor  mediates  cholinergic  agonist-induced
            12.  Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A,   proliferation  of H508 human  colon  cancer  cells.  Cancer Res
                Wess J. Muscarinic acetylcholine receptors: novel opportunities for   2003;63:6744-50.
                drug development. Nat Rev Drug Discov 2014;13:549-60.  32.  Raufman  JP,  Chen  Y,  Zimniak  P,  Cheng  K.  Deoxycholic  acid
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