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65.  Kortmann U, McAlpine JN, Xue H, Guan J, Ha G,  Tully S,   79.  Morelli MP, Calvo E, Ordoñez E,  Wick MJ,  Viqueira BR,
               Shafait S, Lau A, Cranston AN, O’Connor MJ, Huntsman DG,   Lopez-Casas  PP,  Bruckheimer  E,  Calles-Blanco  A,
               Wang  Y, Gilks CB.  Tumor growth inhibition by olaparib in   Sidransky D, Hidalgo M. Prioritizing phase I treatment
               BRCA2 germline-mutated patient-derived ovarian cancer   options through preclinical testing on personalized tumorgraft.
               tissue xenografts. Clin Cancer Res 2011;17:783-91.  J Clin Oncol 2012;30:e45-8.
            66.  Scott CL, Becker MA, Haluska P, Samimi G. Patient-derived   80.  Weroha SJ, Becker MA, Enderica-Gonzalez S, Harrington SC,
               xenograft models to improve targeted therapy in epithelial   Oberg  AL, Maurer MJ, Perkins SE,  AlHilli M, Butler KA,
               ovarian cancer treatment. Front Oncol 2013;3:295.  McKinstry S, Fink S, Jenkins RB, Hou X, Kalli KR,
            67. Gelmon KA,  Tischkowitz M, Mackay H, Swenerton K,   Goodman KM, Sarkaria JN, Karlan BY, Kumar  A,
               Robidoux  A,  Tonkin K, Hirte H, Huntsman D, Clemons M,   Kaufmann SH, Hartmann LC, Haluska P.  Tumorgrafts as
               Gilks B,  Yerushalmi R, Macpherson E, Carmichael J,   in vivo surrogates for women with ovarian cancer. Clin Cancer
               Oza A. Olaparib in patients with recurrent high-grade serous   Res 2014;20:1288-97.
               or poorly differentiated ovarian carcinoma or triple-negative   81. Hidalgo  M,  Bruckheimer  E,  Rajeshkumar  NV,
               breast cancer:  A phase 2, multicentre, open-label,   Garrido-Laguna I, De Oliveira E, Rubio-Viqueira B, Strawn S,
               non-randomised study. Lancet Oncol 2011;12:852-61.  Wick MJ, Martell J, Sidransky D.  A pilot clinical study of
            68.  Fiebig HH, Schuchhardt C, Henss H, Fiedler L, Löhr GW.   treatment guided by personalized tumorgrafts in patients with
               Comparison of tumor response in nude mice and in the   advanced cancer. Mol Cancer Ther 2011;10:1311-6.
               patients. Behring Inst Mitt 1984;74:343-52.    82.  Bankert RB, Egilmez NK, Hess SD. Human-SCID mouse
            69.  Fiebig HH, Dengler W, Hendriks HR. No evidence of tumor   chimeric models for the evaluation of anti-cancer therapies.
               growth stimulation in human tumors in vitro  following   Trends Immunol 2001;22:386-93.
               treatment with recombinant human growth hormone.   83.  Hylander BL, Punt N,  Tang H, Hillman J,  Vaughan M,
               Anticancer Drugs 2000;11:659-64.                   Bshara W, Pitoniak R, Repasky EA. Origin of the vasculature
            70.  Mattern J, Bak M, Hahn EW, Volm M. Human tumor xenografts   supporting growth of primary patient tumor xenografts.
               as model for drug testing. Cancer Metastasis Rev 1988;7:263-84.  J Transl Med 2013;11:110.
            71.  Némati F, Sastre-Garau X, Laurent C, Couturier J, Mariani P,   84.  Klemm F, Joyce JA. Microenvironmental regulation of
               Desjardins L, Piperno-Neumann S, Lantz O,  Asselain B,   therapeutic response in cancer.  Trends Cell Biol 2014; doi:
               Plancher C, Robert D, Peguillet I, Donnadieu MH,   10.1016/j.tcb.2014.11.006.
               Dahmani  A, Bessard MA, Gentien D, Reyes C, Saule S,   85.  Pickup MW, Mouw JK,  Weaver  VM.  The extracellular
               Barillot E, Roman-Roman S, Decaudin D. Establishment   matrix modulates the hallmarks of cancer.  EMBO Rep
               and characterization of a panel of human uveal melanoma   2014;15:1243-53.
               xenografts derived from primary and/or metastatic tumors.   86.  Bankert RB, Balu-Iyer SV, Odunsi K, Shultz LD,
               Clin Cancer Res 2010;16:2352-62.                   Kelleher RJ Jr, Barnas JL, Simpson-Abelson M, Parsons R,
            72.  Peterson JK, Houghton PJ. Integrating pharmacology and   Yokota SJ. Humanized mouse model of ovarian cancer
               in vivo  cancer models in preclinical and clinical drug   recapitulates patient solid tumor progression, ascites formation,
               development. Eur J Cancer 2004;40:837-44.          and metastasis. PLoS One 2011;6:e24420.
            73.  Leggas M, Stewart CF,  Woo MH, Fouladi M, Cheshire PJ,   87.  Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV,
               Peterson JK, Friedman HS, Billups C, Houghton PJ. Relation   Teichmann LL, Saito  Y, Marches F, Halene S, Palucka  AK,
               between Irofulven (MGI-114) systemic exposure and tumor   Manz MG, Flavell RA. Development and function of
               response in human solid tumor xenografts.  Clin Cancer Res   human innate immune cells in a humanized mouse model.
               2002;8:3000-7.                                     Nat Biotechnol 2014;32:364-72.
            74.  Hammer S, Sommer A, Fichtner I, Becker M, Rolff J, Merk J,   88.  Ilie M, Nunes M, Blot L, Hofman V, Long-Mira E, Butori C,
               Klar U, Hoffmann J. Comparative profi ling of the novel   Selva E, Merino-Trigo A, Venissac N, Mouroux J, Vrignaud P,
               epothilone, sagopilone, in xenografts derived from primary   Hofman P. Setting up a wide panel of patient-derived tumor
               non-small cell lung cancer. Clin Cancer Res 2010;16:1452-65.  xenografts of non-small cell lung cancer by improving the
            75.  Wong H, Choo EF, Alicke B, Ding X, La H, McNamara E,   preanalytical steps. Cancer Med 2015;4:201-11.
               Theil FP,  Tibbitts J, Friedman LS, Hop CE, Gould SE.   89.  Hidalgo M,  Amant F, Biankin  AV, Budinská E, Byrne  AT,
               Antitumor activity of targeted and cytotoxic agents in murine   Caldas C, Clarke RB, de Jong S, Jonkers J, Maelandsmo GM,
               subcutaneous tumor models correlates with clinical response.   Roman-Roman S, Seoane J,  Trusolino L,  Villanueva  A.
               Clin Cancer Res 2012;18:3846-55.                   Patient-derived xenograft models:  An emerging platform for
            76.  Malaney P, Nicosia SV, Davé  V. One mouse, one patient   translational cancer research. Cancer Discov 2014;4:998-1013.
               paradigm: New avatars of personalized cancer therapy. Cancer   90.  Xin H, Wang K, Hu G, Xie F, Ouyang K, Tang X, Wang M,
               Lett 2014;344:1-12.                                Wen D, Zhu Y, Qin X. Establishment and characterization of 7
            77.  Nardella C, Lunardi A, Patnaik A, Cantley LC, Pandolfi   PP.   novel hepatocellular carcinoma cell lines from patient-derived
               The APL paradigm and the “co-clinical trial” project. Cancer   tumor xenografts. PLoS One 2014;9:e85308.
               Discov 2011;1:108-16.
            78.  Stebbing J, Paz K, Schwartz GK,  Wexler LH, Maki R,   How to cite this article: Li G. Patient-derived xenograft models for
               Pollock RE, Morris R, Cohen R, Shankar  A, Blackman G,   oncology drug discovery. J Cancer Metastasis Treat 2015;1:8-15.
               Harding  V,  Vasquez D, Krell J, Ciznadija D, Katz  A,
               Sidransky D. Patient-derived xenografts for individualized   Received: 05-11-2014; Accepted: 27-01-2015.
               care in advanced sarcoma. Cancer 2014;120:2006-15.  Source of Support: Nil, Confl ict of Interest: None declared.








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