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Original Article

Ten years of lung cancer in a single center: gender, histology, stage
and survival

Regina Gironés, Pedro López, Rebeca Chulvi, Mamen Cañabate, Torregrosa M. Dolores
Medical Oncology Unit, LluísAlcanyís Hospital, 46800 Xàtiva, Spain.
Correspondence to: Dr. Regina Gironés, Medical Oncology Unit, LluísAlcanyís Hospital, CrtaXàtiva a Silla km 2, 46800 Xàtiva, Valencia, Spain.
E-mail: girones_reg@gva.es

ABSTRACT
Aim: The aim was to describe, in a prospective manner, the clinical, histopathological and epidemiological characteristics of lung
cancer patients who attended as outpatients at the Lluís Alcanyís, Xàtiva Medical Oncology Hospital, València, Spain from January
2004 to July 2014. We also analyzed survival and compared our data with that reported in the literature. Methods: Clinical
and demographic characteristics were analyzed for the entire series and trends were compared by year of diagnosis. Changes in
epidemiology were examined and compared. Results: There were 701 patients (91.4% were men, mean age 67.6). Main histology
was squamous cell carcinoma (41.5%). Squamous cell carcinoma prevailed in men (45.5%) and adenocarcinoma (ADC) in
women (60.3%). The percentage of men with lung cancer and of patients with squamous cell carcinoma was higher than in the
reported worldwide data and remained throughout the 10 years period. Mean survival was low, with < 10% survivors at 5 years.
Stage of disease remained the main prognostic factor for survival. Conclusion: Squamous cell carcinoma continues to be the
most frequent histological type in our area. Male and smoking is associated with lung carcinoma while ADC more often occurs
in females. Over the time, our epidemiological and histological patterns have not changed, possibly in relation to maintenance of
smoking habits.
Key words: Epidemiology, histology, lung cancer, smoking, survival

Introduction are managed at our regional hospital, since 2004, all
such patients who were seen at our outpatient oncology
Epidemiological changes in smoking habits are affecting unit were prospectively registered into a hospital-based
the pattern of lung cancer patients, with perhaps an cancer registry. The aim of the present review is to
increasing number of non-smokers, women involved, and describe their epidemiologic characteristics, focusing on
variation in the occurrence of adenocarcinoma (ADC). [1-3] gender, histology and stage. Trends through years were
Despite treatment advances in lung cancer, it continues to also analyzed.
be one of the most lethal cancers worldwide.
The primary objective was to describe the lung cancer
Lung cancer still ranks as the leading cause of characteristics of patients followed for up to 10 years,
tumor-related death in the world. Some important from 2004 to 2014, and to study the evolution of the
[1]
epidemiological factors are age, gender and histology, disease over these years. In addition, we herein describe
and these have markedly changed in the past few their epidemiologic characteristics, correlations, and
years. Reasons could be non-smoking policies, prognostic factors through these years.
[4]
population aging, women now smoking, improvement
in histological and imaging diagnosis, etc. [2-6] The Methods
patterns of change vary, mainly given the heterogeneity
of smoking habits in different countries. There Patients and methods
is scattered information available concerning the This was a single-center study, prospectively performed
various epidemiological and clinical aspects of lung at the Medical Oncology Unit of our hospital. All
cancer today, especially in Spain and in daily clinical
practice. In order to describe how lung cancer patients This is an open access article distributed under the terms of the Creative
[7]
Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows
others to remix, tweak, and build upon the work non-commercially, as long as
Access this article online the author is credited and the new creations are licensed under the identical
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Website: For reprints contact: reprints@medknow.com
www.jcmtjournal.com
How to cite this article: Gironés R, López P, Chulvi R, Cañabate M,
Dolores TM. Ten years of lung cancer in a single center: gender,
DOI: histology, stage and survival. J Cancer Metastasis Treat 2015;1:201-7.
10.4103/2394-4722.166971
Received: 15-12-2014; Accepted: 20-07-2015.

© 2015 Journal of Cancer Metastasis and Treatment ¦ Published by Wolters Kluwer - Medknow 201