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Topic: Brain tumor cell invasion and metastasis: anatomical,
biological and clinical considerations

Introduction to this special issue on brain tumor cell invasion and
metastasis: anatomical, biological and clinical considerations

Michael A. Grotzer
Department of Oncology, University Children’s Hospital Zürich, Steinwiesstrasse 75, CH-8032 Zürich, Switzerland.
Correspondence to: Prof. Michael A. Grotzer, Department of Oncology, University Children’s Hospital Zürich, Steinwiesstrasse 75, CH-8032
Zürich, Switzerland. E-mail: michael.Grotzer@kispi.uzh.ch

It is my privilege to introduce the readers to this special techniques by using tailored nanocarriers and bioconjugates.
issue entitled “Brain tumor cell invasion and metastasis:
anatomical, biological and clinical considerations”. As Interdisciplinary management of central
cancer is a global epidemic which knows no borders, efforts nervous system metastasis and neoplastic
to better understand biology and to control it should know meningitis: recent developments and future
no borders either. This issue contains a mixture of clinical perspectives
and preclinical scholarly articles that have been written by Ghazaleh Tabatabai et al. (Germany)
scientists from America, Europe, and the Middle East. I hope This article reviews advances in our understanding on the
that the fresh insights represented here will be appreciated molecular mechanisms leading to invasion of tumor cells
by neuro-oncologists and brain cancer researchers across to the CNS and highlights the challenges and perspectives
the translational spectrum. in the field of interdisciplinary management of CNS
metastasis.
The role of the PI3K/AKT/mTOR pathway in
brain tumor metastasis Brain tumor surgery: supplemental
Alexandre Arcaro et al. (Switzerland) intraoperative imaging techniques and future
challenges
This article is emphasizing the role of PI3K/AKT/ Telmo Augusto Barba Belsuzarri et al. (Brazil)
MTOR pathway on glioma growth and metastasis with a This article discusses maximum safe brain tumor resection
specific focus on angiogenesis, glioma cell invasion and techniques including methods that are designed for a precise
inflammation. demarcation of brain tumors and their infiltration zones.
Dissecting brain tumor growth and metastasis Brain infiltration by cancer cells: different
in vitro and ex vivo roads to the same target?
Martin Baumgartner et al. (Switzerland) Mayra Paolillo et al. (Italy)
This article reviews the in vitro and ex vivo techniques used This review illustrates recent findings of genes and cellular
to study growth and dissemination of brain cancer cells mechanisms that have been found to be involved in brain
including organotypic slice culture methods. metastasis and describe the different cell types involved.

Tailored nanocarriers and bioconjugates for Effects of Gas1 on gliomas: a review on current
combating glioblastoma and other brain tumors preclinical studies
Mohamed I. Nounou et al. (Egypt) Jose Segovia et al. (Mexico)
This article reviews blood brain barrier hampered drug This article reviews the potential therapeutic effect of the
delivery and suggests new CNS therapeutics delivery tumor suppressor Gas1 for treatment of GBM.

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How to cite this article: Grotzer MA. Introduction to this special issue
on brain tumor cell invasion and metastasis: anatomical, biological and
DOI: clinical considerations. J Cancer Metastasis Treat 2016;2:147-8.
10.20517/2394-4722.2016.23
Received: 10-05-2016; Accepted: 11-05-2016.

©2016 Journal of Cancer Metastasis and Treatment ¦ Published by OAE Publishing Inc. 147