Page 15 - Read Online

Phase I Study of GRN1005 in Recurrent Malignant Glioma. Clin Cancer WO2012000062 A1)
Res 2013;19:1567-76. 53. Tortorella S, Karagiannis TC. Transferrin receptor-mediated endocytosis:
33. Jones AR, Shusta EV. Blood-brain barrier transport of therapeutics via a useful target for cancer therapy. J Membr Biol 2014;247:291-307.
receptor-mediation. Pharm Res 2007;24:1759-71. 54. Ding H, Ljubimova JY, Holler E, Black KL. Poly (beta malic acid) with
34. Rip J, Schenk GJ, de Boer AG. Differential receptor-mediated drug pendant Leu-Leu-Leu tripeptide for effective cytoplasmic drug delivery.
targeting to the diseased brain. Expert Opin Drug Deliv 2009;6:227-37. In: Cedars-Sinai Medical Center; 2014. (ISBN No. US 8795648 B2)
35. Wang YY, Lui PC, Li JY. Receptor-mediated therapeutic transport across 55. Patil R, Holler E, Black KL, Ljubimova JY. Drug delivery of temozolomide
the blood-brain barrier. Immunotherapy 2009;1:983-93. for systemic based treatment of cancer. In: Cedars-Sinai Medical Center;
36. Papademetriou LT, Porter T. Promising approaches to circumvent the 2014. (ISBN No. US20140161762 A1)
blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer. 56. Weiss N, Miller F, Cazaubon S, Couraud PO. [Blood–brain barrier part
Ther Deliv 2015;6:989-1016. III: therapeutic approaches to cross the blood–brain barrier and target the
37. Demeule M, Regina A, Che C, Poirier J, Nguyen T, Gabathuler R, Castaigne brain]. Rev Neurol 2010;166:284-8.
JP, Beliveau R. Identification and design of peptides as a new drug delivery 57. Estella-Hermoso de Mendoza A, Preat V, Mollinedo F, Blanco-Prieto MJ.
system for the brain. J Pharmacol Exp Ther 2008;324:1064-72. In vitro and in vivo efficacy of edelfosine-loaded lipid nanoparticles against
38. Jefferies W. CNS-targeted conjugates having modified fc regions and glioma. J Control Release 2011;156:421-6.
methods of use thereof. In: Bioasis Technologies Inc.; 2015. (ISBN No. 58. Coley HM. Overcoming multidrug resistance in cancer: clinical studies of
US20150093399 A1) p-glycoprotein inhibitors. Methods Mol Biol 2010;596:341-58.
39. Demeule M, Currie JC, Bertrand Y, Che C, Nguyen T, Regina A, 59. Das M, Sahoo SK. Folate decorated dual drug loaded nanoparticle: role
Gabathuler R, Castaigne JP, Beliveau R. Involvement of the low-density of curcumin in enhancing therapeutic potential of nutlin-3a by reversing
lipoprotein receptor-related protein in the transcytosis of the brain delivery multidrug resistance. PLoS One 2012;7:e32920.
vector angiopep-2. J Neurochem 2008;106:1534-44. 60. Kim MK, Choo H, Chong Y. Water-soluble and cleavable quercetin-amino
40. Kurzrock R, Gabrail N, Chandhasin C, Moulder S, Smith C, Brenner acid conjugates as safe modulators for P-glycoprotein-based multidrug
A, Sankhala K, Mita A, Elian K, Bouchard D, Sarantopoulos J. Safety, resistance. J Med Chem 2014;57:7216-33.
pharmacokinetics, and activity of GRN1005, a novel conjugate of 61. Kim MK, Park KS, Choo H, Chong Y. Quercetin-POM (pivaloxymethyl)
angiopep-2, a peptide facilitating brain penetration, and paclitaxel, in conjugates: Modulatory activity for P-glycoprotein-based multidrug
patients with advanced solid tumors. Mol Cancer Ther 2012;11:308-16. resistance. Phytomedicine 2015;22:778-85.
41. Menlo Park C. Geron Discontinues GRN1005 and Restructures to Focus 62. Romiti N, Tramonti G, Donati A, Chieli E. Effects of grapefruit juice on
on Imetelstat Development in Hematologic Malignancies and Solid the multidrug transporter P-glycoprotein in the human proximal tubular
Tumors with Short Telomeres. In; 2012. cell line HK-2. Life Sci 2004;76:293-302.
42. Che C, Yang G, Thiot C, Lacoste MC, Currie JC, Demeule M, Regina 63. Banks WA, Kumar VB, Darling T, Clayton R. Modulation of blood-brain
A, Beliveau R, Castaigne JP. New Angiopep-modified doxorubicin barrier protein expression. In: St. Louis University; 2010. (ISBN No.
(ANG1007) and etoposide (ANG1009) chemotherapeutics with increased US20100196393 A1)
brain penetration. J Med Chem 2010;53:2814-24. 64. McChesney JD, Tapolsky G, Emerson DL, Marshall J, Ahmed T, Cohn A,
43. Bertrand Y, Currie JC, Demeule M, Regina A, Che C, Abulrob A, Fatehi Kurman M, Modiano M. Taxane analogs for the treatment of brain cancer. In:
D, Sartelet H, Gabathuler R, Castaigne JP, Stanimirovic D, Beliveau R. Tapestry Pharmaceuticals, Inc.; 2011. (ISBN No. US 20110318334 A1)
Transport characteristics of a novel peptide platform for CNS therapeutics. 65. Tosi G, Vergoni AV, Ruozi B, Bondioli L, Badiali L, Rivasi F, Costantino
J Cell Mol Med 2010;14:2827-39. L, Forni F, Vandelli MA. Sialic acid and glycopeptides conjugated PLGA
44. Thomas FC, Taskar K, Rudraraju V, Goda S, Thorsheim HR, Gaasch JA, nanoparticles for central nervous system targeting: In vivo pharmacological
Mittapalli RK, Palmieri D, Steeg PS, Lockman PR, Smith QR. Uptake of evidence and biodistribution. J Control Release 2010;145:49-57.
ANG1005, a novel paclitaxel derivative, through the blood-brain barrier 66. Bazile D, Prud’homme C, Bassoullet MT, Marlard M, Spenlehauer G,
into brain and experimental brain metastases of breast cancer. Pharm Res Veillard M. Stealth Me. PEG-PLA nanoparticles avoid uptake by the
2009;26:2486-94. mononuclear phagocytes system. J Pharm Sci 1995;84:493-8.
45. Xin H, Jiang X, Gu J, Sha X, Chen L, Law K, Chen Y, Wang X, Jiang 67. Niidome T, Yamagata M, Okamoto Y, Akiyama Y, Takahashi H, Kawano
Y, Fang X. Angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon- T, Katayama Y, Niidome Y. PEG-modified gold nanorods with a stealth
caprolactone) nanoparticles as dual-targeting drug delivery system for character for in vivo applications. J Control Release 2006;114:343-7.
brain glioma. Biomaterials 2011;32:4293-305. 68. Weissenbock A, Wirth M, Gabor F. WGA-grafted PLGA-nanospheres:
46. Shen J, Zhan C, Xie C, Meng Q, Gu B, Li C, Zhang Y, Lu W. Poly preparation and association with Caco-2 single cells. J Control Release
(ethylene glycol)-block-poly(D, L-lactide acid) micelles anchored with 2004;99:383-92.
angiopep-2 for brain-targeting delivery. J Drug Target 2011;19:197-203. 69. Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and
47. Sun X, Pang Z, Ye H, Qiu B, Guo L, Li J, Ren J, Qian Y, Zhang Q, diagnosis. Adv Drug Deliv Rev 2002;54:631-51.
Chen J, Jiang X. Co-delivery of pEGFP-hTRAIL and paclitaxel to brain 70. Zhang P, Ling G, Sun J, Zhang T, Yuan Y, Sun Y, Wang Z, He Z.
glioma mediated by an angiopep-conjugated liposome. Biomaterials Multifunctional nanoassemblies for vincristine sulfate delivery to
2012;33:916-24. overcome multidrug resistance by escaping P-glycoprotein mediated
48. Gaillard PJ. Conjugates for targeted drug delivery across the blood-brain efflux. Biomaterials 2011;32:5524-33.
barrier. In: to-BBB Holding B.V.; 2013. (ISBN No. EP2308514 B1) 71. Petkar KC, Chavhan SS, Agatonovik-Kustrin S, Sawant KK.
49. Gaillard PJ, De Boer AG, Brink A. Differentially Expressed Nucleic Acids Nanostructured materials in drug and gene delivery: a review of the state
in the Blood–Brain Barrier Under Inflammatory Conditions. In: Gaillard, of the art. Crit Rev Ther Drug Carrier Syst 2011;28:101-64.
P.J.De Boer, A.G. Brink, A.; 2008. (ISBN No. US20080213179 A1) 72. Meyers JD, Doane T, Burda C, Basilion JP. Nanoparticles for imaging and
50. Gaillard PJ. Glutathione-based drug delivery system. In: To-Bbb Holding treating brain cancer. Nanomedicine 2013;8:123-43.
B.V.; 2010. (ISBN No. WO2010095940 A2) 73. Chen Y, Liu L. Modern methods for delivery of drugs across the blood-
51. Dickerson IM, Brown EB. Methods of treating cancer using an agent that brain barrier. Adv Drug Deliv Rev 2012;64:640-65.
modulates activity of the calcitonin-gene related peptide (“CGRP”) receptor. 74. De Jong WH, Borm PJ. Drug delivery and nanoparticles: applications and
In: University Of Rochester; 2011. (ISBN No. US 20110189205 A1) hazards. Int J Nanomedicine 2008;3:133.
52. Furness S, Johns T, Wookey PJ. Diagnosis and treatment of brain 75. Garcia-Garcia E, Andrieux K, Gil S, Couvreur P. Colloidal carriers and
tumors. In: Welcome Receptor Antibodies Pty Ltd; 2012. (ISBN No. blood-brain barrier (BBB) translocation: a way to deliver drugs to the

120
Journal of Cancer Metastasis and Treatment ¦ Volume 2 ¦ March 15, 2016 ¦