Page 37 - Read Online

Page 16 of 17 Wenner et al. J Cancer Metastasis Treat 2020;6:33 I http://dx.doi.org/10.20517/2394-4722.2020.73

49. Ghosh K, De S, Mukherjee S, Das S, Ghosh AN, et al. Withaferin A induced impaired autophagy and unfolded protein response in human
breast cancer cell-lines MCF-7 and MDA-MB-231. Toxicol In Vitro 2017;44:330-8.
50. Muniraj N, Siddharth S, Nagalingam A, Walker A, Woo J, et al. Withaferin A inhibits lysosomal activity to block autophagic flux and
induces apoptosis via energetic impairment in breast cancer cells. Carcinogenesis 2019.
51. Okamoto S, Tsujioka T, Suemori S, Kida J, Kondo T, et al. Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines
by inhibiting cell cycle progression. Cancer Sci 2016;107:1302-14.
52. Li X, Zhu F, Jiang J, Sun C, Zhong Q, et al. Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances
apoptosis induced by ER stress aggravators in human pancreatic cancer cells. Autophagy 2016;12:1521-37.
53. Nishikawa Y, Okuzaki D, Fukushima K, Mukai S, Ohno S, et al. Withaferin A induces cell death selectively in androgen-independent
prostate cancer cells but not in normal fibroblast cells. PLoS One 2015;10:e0134137.
54. Rah B, ur Rasool R, Nayak D, Yousuf SK, Mukherjee D, et al. PAWR-mediated suppression of BCL2 promotes switching of 3-azido
withaferin A (3-AWA)-induced autophagy to apoptosis in prostate cancer cells. Autophagy 2015;11:314-31.
55. Vyas AR, Singh SV. Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal
lactone. AAPS J 2014;16:1-10.
56. Hahm ER, Singh SV. Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells. Curr Cancer Drug Targets
2013;13:640-50.
57. Siddharth S, Muniraj N, Saxena NK, Sharma D. Concomitant inhibition of cytoprotective autophagy augments the efficacy of withaferin
A in hepatocellular carcinoma. Cancers (Basel) 2019;11:453.
58. Spagnuolo C, Russo GL, Orhan IE, Habtemariam S, Daglia M, et al. Genistein and cancer: current status, challenges, and future
directions. Adv Nutr 2015;6:408-19.
59. Singletary K, Milner J. Diet, Autophagy and cancer: a review. Cancer Epidemiol Biomarkers Prev 2008;17:1596-610.
60. Gossner G, Choi M, Tan L, Fogoros S, Griffith KA, et al. Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells.
Gynecol Oncol 2007;105:23-30.
61. Nazim UM, Park SY. Genistein enhances TRAIL-induced cancer cell death via inactivation of autophagic flux. Oncol Rep 2015;34:2692-8.
62. Suzuki R, Kang Y, Li X, Roife D, Zhang R, et al. Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and
autophagy in human pancreatic cancer cells. Anticancer Res 2014;34:4685-92.
63. Prietsch RF, Monte LG, da Silva FA, Beira FT, Del Pino FA, et al. Genistein induces apoptosis and autophagy in human breast MCF-7
cells by modulating the expression of proapoptotic factors and oxidative stress enzymes. Mol Cell Biochem 2014;390:235-42.
64. Pons DG, Nadal-Serrano M, Torrens-Mas M, Oliver J, Roca P. The Phytoestrogen Genistein Affects Breast Cancer Cells Treatment
Depending on the ERα/ERβ Ratio. J Cell Biochem 2016;117:218-29.
65. Zhang X, Cook KL, Warri A, Cruz IM, Rosim M, et al. Lifetime Genistein Intake Increases the Response of Mammary Tumors to
Tamoxifen in Rats. Clin Cancer Res 2017;23:814-24.
66. Nakamura Y, Yogosawa S, Izutani Y, Watanabe H, Otsuji E, et al. A combination of indol-3-carbinol and genistein synergistically induces
apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Mol Cancer 2009;8:100.
67. Mohan N, Chakrabarti M, Banik NL, Ray SK. Combination of LC3 shRNA plasmid transfection and genistein treatment inhibited
autophagy and increased apoptosis in malignant neuroblastoma in cell culture and animal models. PLoS One 2013;8:e78958.
68. Pool H, Campos-Vega R, Herrera-Hernández MG, García-Solis P, García-Gasca T, et al. Development of genistein-PEGylated silica
hybrid nanomaterials with enhanced antioxidant and antiproliferative properties on HT29 human colon cancer cells. Am J Transl Res
2018;10:2306-23.
69. Zhang Z, Jin F, Lian X, Li M, Wang G, et al. Genistein promotes ionizing radiation-induced cell death by reducing cytoplasmic Bcl-xL
levels in non-small cell lung cancer. Sci Rep 2018;8:328.
70. Fan Y, Chen M, Meng J, Yu L, Tu Y, et al. Arsenic trioxide and resveratrol show synergistic anti-leukemia activity and neutralized
cardiotoxicity. PLoS One 2014;9:e105890.
71. Gali-Muhtasib H, Hmadi R, Kareh M, Tohme R, Darwiche N. Cell death mechanisms of plant-derived anticancer drugs: beyond
apoptosis. Apoptosis 2015;20:1531-62.
72. Castro L, Gao X, Moore AB, Yu L, Di X, et al. A high concentration of genistein induces cell death in human uterine leiomyoma cells by
autophagy. Expert Opin Environ Biol 2016;5.
73. Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, et al. Evidence that curcumin suppresses the growth of malignant gliomas in vitro
and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol
2007;72:29-39.
74. Shinojima N, Yokoyama T, Kondo Y, Kondo S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced
autophagy. Autophagy 2007;3:635-7.
75. Seo SU, Woo SM, Lee HS, Kim SH, Min KJ, et al. mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane
permeabilization-mediated autophagy. Oncogene 2018;37:5205-20.
76. Seo SU, Woo SM, Lee HS, Kim SH, Min KJ, et al. mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane
permeabilization-mediated autophagy. Oncogene 2018;37:5205-20.
77. Fu Y, Chang H, Peng X, Bai Q, Yi L, et al. Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/
β-catenin signaling pathway. PLoS One 2014;9:e102535.
78. Fan Y, Chiu JF, Liu J, Deng Y, Xu C, et al. Resveratrol induces autophagy-dependent apoptosis in HL-60 cells. BMC Cancer 2018;18:581.
79. Trincheri NF, Follo C, Nicotra G, Peracchio C, Castino R, et al. Resveratrol-induced apoptosis depends on the lipid kinase activity of