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Su et al. J Cancer Metastasis Treat 2020;6:19 I  http://dx.doi.org/10.20517/2394-4722.2020.48                                Page 13 of 21

                A











                                  B









               Figure 7. Schematic view of longitudinal magnetization components after the application of a 90° rf pulse. The longitudinal component
               M z  recovers to equilibrium value through an exponential process (A); Longitudinal relaxation time T1 at which the M z  recovers to 63% of
               its equilibrium value (B) [82]  (reprinted with permission from IOP Publishing, Ltd)











































               Figure 8. Schematic view of transverse magnetization components after the application of a 90° rf pulse. The transverse component
               M xy  decays to 37% of its initial value. The observed T2* relaxation time as a result of local field non-uniformities [81]

               MNPs as contrast agents in NMR-based applications
               In NMR-based applications, T1, T2, and T2* are used as metrics. Nowadays, NMR has been widely used
               for determining the structures of organic compounds and biomolecules as well as in magnetic resonance
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