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Page 12 of 20 Vidoni et al. J Cancer Metastasis Treat 2021;7:4 I http://dx.doi.org/10.20517/2394-4722.2020.95

Table 1. The table shows the autophagy targets of miRNAs in female malignant tumors
ATG gene Role miRNA Cancer Ref.
ATG2 Phagophore formation miR-30d Ovarian, [95]
Breast
ATG4 LC3 maturation miR-376b Breast [104]
let-7a Ovarian [94]
miR-101 Breast [135]
miR-34C Breast [98]
ATG5 Autophagosome formation miR-30d Ovarian, [95]
Breast
miR-181a Breast [136]
ATG7 LC3 maturation miR-204 Ovarian [137]
ATG9A Phagophore formation miR-29b Ovarian [96]
miR-34a Ovarian [94]
let-7a Ovarian [94]
miR-15b Ovarian [94]
ATG12 Autophagosome formation miR-30d Ovarian, [95]
Breast
ATG13 Autophagy initiation complex miR-15b Ovarian [94]
ATG14 Autophagy nucleation complex miR-152 Ovarian [138]
miR-15b Ovarian [94]
ATG16L Autophagosome formation miR-20a Breast [105]
let-7a Ovarian [94]
BECLIN1 Autophagy interactome - Nucleation miR-20a Breast [105]
Complex miR-124-3p Breast [139]
miR-30d Ovarian, [95]
Breast
miR-30a Breast [103]
miR-376b Breast [104]
BCL2 BECLIN 1 interactor by BH3 domains miR-7-5p Cervical [99]
BNIP3L Mitophagy miR-30d Ovarian, [95]
Breast
DIRAS3 BECLIN 1 interactor - Positive miR-1305 Ovarian [109]
(ARH-I) activator of autophagy interactome miR-1260a
miR-141-3p
miR-424-5p
miR-15a-5p
miR-7-5p
DRAM1 DNA Damage Regulated Autophagy miR-26b Breast [140]
Modulator 1; positive regulator of
autophagy
LC3 Autophagosome maturation miR-204 Ovarian [137]
mTOR mammalian Target of Rapamycin; miR-18a Breast [141]
negative regulator of autophagy
PTEN Phosphatase and tensin homologue; miR-21 Breast, [116]
Positive regulator of autophagy Ovarian, [117]
Cervical [118]
miR-17-5p Ovarian [142]
miR-222 Breast [143,144]
miR-29a Breast [143]
miR-205 Endometrial [145]
miR-19 Breast [146]
RAPTOR Component of mTOR Complex 1 miR-155 Ovarian [94]
TSC1 Tuberous sclerosis 1; negative miR-130a Ovarian [147]
regulator of mTOR let-7a Ovarian [94]
miR-15b Ovarian [94]
miR-21 Ovarian [94]
ULK1 Autophagy initiation complex miR-489 Breast [148]
miR-25 Breast [149]
UVRAG Nucleation complex miR-125b Ovarian [94]
MiRNAs: micro-RNAs; ATG: autophagy-related gene; PTEN: phosphatase and tensin homolog